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中文名稱：RNPS1兔多克隆抗體
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貨號：CSB-PA019907GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：RNPS1
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別名：E5.1 antibody; MGC117332 antibody; RNA binding protein S1 serine rich domain antibody; RNA binding protein with serine rich domain 1 antibody; RNA-binding protein with serine-rich domain 1 antibody; RNPS 1 antibody; rnps1 antibody; RNPS1_HUMAN antibody; SR protein antibody; SR related protein LDC2 antibody; SR-related protein LDC2 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human RNPS1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
引用文獻
- The Altered Proteomic Landscape in Renal Tubular Epithelial Cells under High Oxalate Stimulation SY Hong, BL Qin,Biology,2024
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靶點詳情
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功能：Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions.
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基因功能參考文獻：
- ubiquitin-specific protease 4 (USP4) is a binding partner of RNPS1. PMID: 27990632
- SRBD1 gene polymorphism is associated with the development of HTG as well as NTG, including late-onset NTG. PMID: 21508110
- The phosphorylation of RNPS1 at Ser-53 influences the efficiencies of both splicing and translation. PMID: 15684395
- RNPS1 is able to function together with ASF/SF2 to form ribonucleoprotein complexes on nascent transcripts, and thereby prevent formation of transcriptional R-loops. PMID: 17959926
- has a role in mRNA surveillance (detecting mRNAs with truncated open reading frames and subjecting them to nonsense-mediated mRNA decay (NMD)) PMID: 11546874
- binds to Upf complexes which bind upstream of mRNA exon-exon junctions PMID: 11546873
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亞細胞定位：Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles.
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蛋白家族：Splicing factor SR family
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組織特異性：Ubiquitous.
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數據庫鏈接：
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