RNMT Antibody
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中文名稱：RNMT兔多克隆抗體
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貨號：CSB-PA019902GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：RNMT
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別名：DKFZp686H1252 antibody; EC 2.1.1.56 antibody; hcm1p antibody; hCMT1 antibody; HCMT1a antibody; hCMT1c antibody; hMet antibody; hypothetical protein KIAA0396 antibody; KIAA0398 antibody; MCES_HUMAN antibody; MET antibody; mRNA (guanine 7)methyltransferase antibody; mRNA (guanine N(7)) methyltransferase antibody; mRNA (guanine-N(7)-)-methyltransferase antibody; mRNA cap guanine-N7 methyltransferase antibody; mRNA cap methyltransferase antibody; OTTHUMP00000162509 antibody; RG7MT1 antibody; RNA (guanine 7) methyltransferase antibody; RNA guanine 7 methyltransferase antibody; Rnmt antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human RNMT
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC,IF
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.
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基因功能參考文獻：
- Results identify a cytoplasmic pool of RNMT which is a component of the cytoplasmic capping complex, and demonstrate its function as the methyltransferase that catalyzes the final maturation step in cap homeostasis. PMID: 28981715
- MYC promotes mRNA cap methylation and protein production of Wnt/beta-catenin signaling transcripts through recruitment of cyclin-dependent kinase 7 (CDK7) and consequently RNMT to gene promoters. PMID: 27899423
- RNMT-RAM complex coordinates mRNA processing with ribosome production. PMID: 27934633
- CDK1-Cyclin B1 activates RNMT, coordinating mRNA cap methylation with G1 phase transcription. PMID: 26942677
- High RNMT expression is associated with liver cancer. PMID: 24763612
- Data suggest the C-terminal nuclear localization domain (QYP) is critical for RAM (RNMT-activating mini protein) to enter the cell nucleus where RAM activates RNMT resulting in mRNA cap methylation. TNPO1/TNPO2 mediate RAM nuclear entry. PMID: 24200467
- The RNMT N-terminal domain is required for transcript expression, translation and cell proliferation. PMID: 23863084
- Nuclear localization of cap methyltransferase is mediated by alternative nuclear localization signal motifs PMID: 15767670
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亞細胞定位：Nucleus.
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蛋白家族：Class I-like SAM-binding methyltransferase superfamily, mRNA cap 0 methyltransferase family
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組織特異性：Widely expressed.
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數據庫鏈接：
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