RNF6 Antibody, HRP conjugated
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中文名稱：RNF6兔多克隆抗體, HRP偶聯
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貨號：CSB-PA897080LB01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) RNF6 Polyclonal antibody
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Uniprot No.：
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基因名：RNF6
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別名：E3 ubiquitin-protein ligase RNF6 antibody; Ring finger protein (C3H2C3 type) 6 antibody; Ring finger protein 6 antibody; RING H2 protein antibody; RING H2 protein RNF6 antibody; RNF 6 antibody; RNF6 antibody; RNF6_HUMAN antibody; SPG2 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human E3 ubiquitin-protein ligase RNF6 protein (1-298AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.
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基因功能參考文獻：
- High RNF6 expression is associated with breast cancer. PMID: 28223545
- This study thus suggests that RNF6 overexpression in leukemia is under the direction of PBX1 and that the PBX1/RNF6 axis can be developed as a novel therapeutic target of leukemia. PMID: 26971355
- Rnf6 controls cellular LIMK1 concentrations and indicate a new function for the ubiquitin/proteasome system in regulating local growth cone actin dynamics PMID: 16204183
- Results describe thet cloning and identification of a novel RNF6 transcriptional splice variant, Spg2, in human development. PMID: 18368307
- Functional anaylysis of the mouse homolog PMID: 11971979
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相關疾病：Esophageal cancer (ESCR)
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亞細胞定位：Nucleus. Cytoplasm. Cell projection, axon. Nucleus, PML body.
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蛋白家族：RNF12 family
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組織特異性：Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues.
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數據庫鏈接：
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