RNASEH2C Antibody

說明書

產品詳情

Uniprot No.：

Q8TDP1
基因名：

RNASEH2C
別名：

RNASEH2C antibody; AYP1 antibody; Ribonuclease H2 subunit C antibody; RNase H2 subunit C antibody; Aicardi-Goutieres syndrome 3 protein antibody; AGS3 antibody; RNase H1 small subunit antibody; Ribonuclease HI subunit C antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Human RNASEH2C
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
基因功能參考文獻：
1. This study reviewed that Neurologic Phenotypes Associated with Mutations in RNASEH2C in patients with Aicardi-Goutieres Syndrome. PMID: 27643693
2. Examination of the effect of several Aicardi-Goutieres Syndrome-related mutations in the C subunit of RNase H2. PMID: 19015152
3. Describes an RNASEH2C pseudogene that is located close to the SRY gene on chromosome Y. PMID: 8244390
相關疾病：

Aicardi-Goutieres syndrome 3 (AGS3)
亞細胞定位：

Nucleus.
蛋白家族：

RNase H2 subunit C family
組織特異性：

Widely expressed.
數據庫鏈接：

HGNC: 24116

OMIM: 610329

KEGG: hsa:84153

STRING: 9606.ENSP00000308193

UniGene: Hs.718438

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