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中文名稱：RNASEH2A兔多克隆抗體
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貨號：CSB-PA019805GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：RNASEH2A
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別名：RNASEH2A antibody; RNASEHI antibody; RNHIA antibody; Ribonuclease H2 subunit A antibody; RNase H2 subunit A antibody; EC 3.1.26.4 antibody; Aicardi-Goutieres syndrome 4 protein antibody; AGS4 antibody; RNase H(35) antibody; Ribonuclease HI large subunit antibody; RNase HI large subunit antibody; Ribonuclease HI subunit A antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human RNASEH2A
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
引用文獻
- Depletion of RNASEH2 Activity Leads to Accumulation of DNA Double-strand Breaks and Reduced Cellular Survivability in T Cell Leukemia D Ghosh,Journal of molecular biology,2023
產(chǎn)品評價
相關產(chǎn)品
靶點詳情
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功能：Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
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基因功能參考文獻：
- The expression levels of RNASEH2A, CDK1, and CD151 and their combination could predict the survival of renal cell carcinoma patients. PMID: 29843367
- RNaseH2A may be involved in human gliomagenesis. PMID: 27176716
- This study reviewed that Neurologic Phenotypes Associated with Mutations in RNASEH2A in patients with Aicardi-Goutieres Syndrome. PMID: 27643693
- RNase H2 complex is assembled in the cytosol and imported into the nucleus in an RNase H2B-dependent manner. PMID: 24986920
- Studies indicate that most antiviral-defense systems involve RNase H-like enzymes destroying invading nucleic acids, RNA, or DNA. PMID: 25703292
- study identified two synonymous variants in RNASEH2A that result in loss of RNase H2 enzyme function and the consequent Aicardi-Goutieres syndrome phenotype PMID: 23592335
- analysis of the RNase H2A subunit mutations that cause Aicardi-Goutieres syndrome PMID: 21454563
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相關疾病：Aicardi-Goutieres syndrome 4 (AGS4)
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亞細胞定位：Nucleus.
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蛋白家族：RNase HII family, Eukaryotic subfamily
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數(shù)據(jù)庫鏈接：
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