RLN3 Antibody

說明書

中文名稱：

RLN3兔多克隆抗體
貨號：

CSB-PA006898
規格：

￥1090
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q8WXF3
基因名：

RLN3
別名：

RLN3 antibody; INSL7 antibody; RXN3 antibody; ZINS4 antibody; UNQ6188/PRO20213 antibody; Relaxin-3 antibody; Insulin-like peptide INSL7 antibody; Insulin-like peptide 7 antibody; Prorelaxin H3) [Cleaved into: Relaxin-3 B chain; Relaxin-3 A chain] antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from the Internal region of Human Relaxin 3.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:40000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May play a role in neuropeptide signaling processes. Ligand for LGR7, RXFP3 and RXFP4.
基因功能參考文獻：
1. Serum level of relaxin-3 hormone is an important mediator in the pathophysiological process of normal puberty being significantly decreased in males with delayed puberty. PMID: 28786126
2. Therefore, we conclude that stapling of the relaxin3 B chain does not compromise its ability to activate RXFP3 and is a promising method for developing stable peptide agonists and antagonists of RXFP3 to aid relaxin-3/RXFP3 research. PMID: 27498038
3. the relaxin-3 B-chain C-terminus changes from the original folding-back conformation to an extended conformation during binding with RXFP3, to allow its B27Trp and B26Arg residues to interact with the Trp138 and Glu141 residues of RXFP3, respectively. PMID: 27193232
4. In a population of acute HF patients, admission relaxin serum levels were associated with clinical and echocardiographic markers of pulmonary hypertension, RV dysfunction, and overload, suggesting a role for circulating relaxin as a biomarker in this setting. PMID: 27488261
5. the negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3 PMID: 27353281
6. Relaxin-3 is a high-efficacy agonist at RXFP4 with a comparable signal transduction profile to INSL5. PMID: 27888281
7. Serum concentrations of relaxin showed a positive association to duration of gestation among women with miscarriage but no association to duration of gestation among women with spontaneous onset of labour. PMID: 26272327
8. Review of research depicts the connection of relaxin-3 with phenomena such as feeding behavior, spatial memory, sleep/wake cycle or modulation of pituitary gland hormone secretion. PMID: 24988606
9. we demonstrated distinct patterns of signalling for H3 and H2 relaxin and R3(BDelta23-27)R/I5 at the RXFP3 receptor PMID: 24641548
10. Glu141 and Asp145 of the RXFP3 interact with the highly conserved arginine residues of relaxin-3. PMID: 24615237
11. Mutant relaxin-3 shows a significant decrease in receptor-activation potency towards RXFP4. PMID: 24802387
12. Relaxin-2 or relaxin-3 levels are not related to component traits in patients with diabetes. PMID: 23994775
13. metabolic syndrome is associated with increased serum relaxin-3 levels in women PMID: 23018057
14. [review] Relaxin-3 (RXF3P) is expressed within GABA neurons of the brainstem including an area known as the nucleus incertus; ascending relaxin-3 projections innervate a broad range of RXFP3-rich forebrain areas. PMID: 21693186
15. H3 relaxin exerts antifibrotic actions via RXFP1 receptor PMID: 21229994
16. Relaxin-3 and receptors in the human and rhesus brain and reproductive tissues. PMID: 19778557
17. relaxin-3/INSL7 is a ligand for GPCR142 PMID: 14522967
18. GPCR135 is the receptor for relaxin-3 PMID: 14522968
19. RLN3 chimeric peptide is a potential tool to study in vivo function of GPCR135. PMID: 15465925
20. Intracerebroventricular injections of human relaxin-3 (H3) to satiated rats significantly increased food intake. PMID: 15845619
21. NMR spectroscopy and simulated annealing calculations were used to determine the three-dimensional structure of relaxin-3 and to identify key structural differences between the human relaxins. PMID: 15956686
22. functional response to H3 relaxin and other relaxin/insulin peptides of GPCR135 expressed in CHO-K1 cells was measured in the cytosensor microphysiometer and analyzed using inhibitors of signal transduction proteins PMID: 15956730
23. Results describe the solution structure of human relaxin-3. PMID: 16365033
24. Results decribe the structural and functional aspects of the interaction between relaxin-3 and its receptor, RXFP3. PMID: 19152634
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亞細胞定位：

Secreted.
蛋白家族：

Insulin family
數據庫鏈接：

HGNC: 17135

OMIM: 606855

KEGG: hsa:117579

STRING: 9606.ENSP00000397415

UniGene: Hs.352155

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