RIT2 Antibody

中文名稱：

RIT2兔多克隆抗體
貨號：

CSB-PA860769LA01HU
規格：

￥440
圖片：
Immunofluorescence staining of A549 cells with CSB-PA860769LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA860769LA01HU at dilution of 1:100
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) RIT2 Polyclonal antibody
Uniprot No.：

Q99578
基因名：

RIT2
別名：

GTP binding protein Rit2 antibody; GTP binding protein Roc2 antibody; GTP-binding protein Rit2 antibody; Ras like protein expressed in neurons antibody; Ras like without CAAX 2 antibody; Ras like without CAAX protein 2 antibody; Ras-like protein expressed in neurons antibody; Ras-like without CAAX protein 2 antibody; RIBA antibody; Ric (Drosophila) like antibody; Ric like antibody; Ric like, expressed in neurons antibody; RIN antibody; RIT2 antibody; RIT2_HUMAN antibody; ROC2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human GTP-binding protein Rit2 protein (1-150AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，RIT2 Antibody (CSB-PA860769LA01HU)，的標記方式是Non-conjugated。對于RIT2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA860769LB01HU	RIT2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA860769LC01HU	RIT2 Antibody, FITC conjugated
Biotin	CSB-PA860769LD01HU	RIT2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator.
基因功能參考文獻：
1. RIT2 gene was recently introduced as a susceptibility gene in neurological disorders, a group of major problems in human society affecting millions of people worldwide. Several variants, including single nucleotide polymorphisms and CNVs, have been identified and studied in different populations. PMID: 29860660
2. Significant association of RIT2 Polymorphisms was observed between rs12456492 and two disorders, Parkinson's disease and essential tremor PMID: 26941103
3. An RIT2 gene variant was found to be a risk factor for autism spectrum disorder in Iranian patients. PMID: 28190241
4. Findings indicate for the first time, selective advantage for a human-specific allele at an short tandem repeat locus in the human RIT2 core promoter. PMID: 28214997
5. RIT2 rs12456492 do not increase the risk of developing Parkinson's in Han Chinese. PMID: 27889863
6. The current meta-analysis suggested that rs12456492 might be associated with increased PD risk in Asian populations, but studies using larger sample sizes and different ethnic populations will be needed to further confirm this association. PMID: 26334395
7. findings increase the likelihood of association between Parkinson's disease and RIT2 variant in Asian populations PMID: 25146456
8. performed a case-control replication study in this population and investigated RIT2 rs12456492 variant in a large cohort of Chinese Han individuals PMID: 25559334
9. Its polymorphism is associated with Parkinson's disease in a Han Chinese population. PMID: 25457028
10. The data of this study suggested that the RIT2 polymorphisms are associated with Parkinson disease etiology. PMID: 25534083
11. the G allele, GG and GA genotype of rs12456492(A/G) polymorphism may increase the risk of Parkinson disease. [meta-analysis] PMID: 26188085
12. failed to replicate the RIT2 rs12456492 variant as a genetic risk factor for Parkinson's disease in our population. PMID: 23635658
13. These studies confirm the expression of RIT2 in retinal neuronal cells. PMID: 23805044
14. This meta-analysis identifies a novel Parkinson's disease locus, RIT2, that replicates several previously identified loci on chromosome 18. PMID: 22451204
15. Rin interacts directly with dopamine transporter DAT in a protein kinase (PK)C-regulated manner and is required for PKC-mediated DAT internalization. PMID: 21957239
16. Modulates the activation of the Brn-3a regulated egr-1 promoter by the N-terminal domain of Brn-3a PMID: 12934100
17. Neuron-specific small GTPase Rin is involved in downstream signaling of plexin B3. PMID: 16122393
18. observations establish Rin as a neuronal specific regulator of neurotrophin signaling, required to couple NGF stimulation to sustain activation of p38 MAP kinase and b-Raf signaling cascades required for neuronal development PMID: 16157584
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亞細胞定位：

Nucleus. Cell membrane.
蛋白家族：

Small GTPase superfamily, Ras family
組織特異性：

Neuron-specific.
數據庫鏈接：

HGNC: 10017

OMIM: 609592

KEGG: hsa:6014

STRING: 9606.ENSP00000321805

UniGene: Hs.464985

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