RHOBTB3 Antibody

說明書

中文名稱：

RHOBTB3兔多克隆抗體
貨號(hào)：

CSB-PA008260
規(guī)格：

￥1090
圖片：
Western Blot analysis of K562 cells using RHOBTB3 Polyclonal Antibody

Western blot analysis of customer's lysis using RHOBTB3 antibody.
其他：

產(chǎn)品詳情

Uniprot No.：

O94955
基因名：

RHOBTB3
別名：

RHOBTB3 antibody; KIAA0878 antibody; Rho-related BTB domain-containing protein 3 antibody; EC 3.6.1.- antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from the Internal region of Human RHOBTB3.
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

WB, IHC, ELISA

推薦稀釋比：

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9.
基因功能參考文獻(xiàn)：
1. RHOBTB3 serves as a scaffold to organize a multi-subunit complex that promotes the hydroxylation, ubiquitination and degradation of HIFalpha. PMID: 26215701
2. Reveal a novel role for a RhoBTB3 in catalyzing cyclin E turnover during S phase, as well as an unexpected, essential role for the Golgi as a ubiquitylation platform for cell cycle control. PMID: 24145166
3. The interaction between RhoBTB3 and the 5-HT7a receptor strongly inhibits proteasomal degradation of the 5-HT7a receptor. PMID: 22245496
4. Study reports that the atypical Rho GTPase family member, RhoBTB3, binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. PMID: 19490898
亞細(xì)胞定位：

Golgi apparatus.
組織特異性：

Ubiquitous. Highly expressed in neural and cardiac tissues, pancreas, placenta and testis.
數(shù)據(jù)庫鏈接：

HGNC: 18757

OMIM: 607353

KEGG: hsa:22836

STRING: 9606.ENSP00000369318

UniGene: Hs.445030

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