RHEBL1 Antibody, Biotin conjugated

說明書

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) RHEBL1 Polyclonal antibody
Uniprot No.：

Q8TAI7
基因名：

RHEBL1
別名：

RHEBL1 antibody; GTPase RhebL1 antibody; Ras homolog enriched in brain like-1 c antibody; RhebL1c antibody; Ras homolog enriched in brain-like protein 1 antibody; Rheb-like protein 1 antibody; Rheb2 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human GTPase RhebL1 protein (1-180AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2.
基因功能參考文獻：
1. High RHEBL1 expression is associated with lung cancer. PMID: 28209923
2. These results establish CAD as a downstream effector of Rheb and suggest a possible role of Rheb in regulating de novo pyrimidine nucleotide synthesis.(Rheb small GTPases, which consist of Rheb1 and Rheb2 (also known as RhebL1) PMID: 25422319
3. RhebL1 may be impacting the mTOR pathway in a different manner than Rheb1. PMID: 21655954
4. Data show that Rheb like-1 protein (RhebL1) rescues mTOR signaling during nutrient withdrawal, and identify critical residues in Rheb and RhebL1 which are required for their efficient activation of mTOR signaling. PMID: 16098514
5. RHEBL1 is a positive regulator of NF-kappa B-mediated gene transcription. PMID: 16328882
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亞細胞定位：

Endomembrane system; Lipid-anchor; Cytoplasmic side. Cytoplasm.
蛋白家族：

Small GTPase superfamily, Rheb family
組織特異性：

Ubiquitously expressed. Expression increased at least 2-fold in several tumor cell lines.
數(shù)據(jù)庫鏈接：

HGNC: 21166

KEGG: hsa:121268

STRING: 9606.ENSP00000301068

UniGene: Hs.159013

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