RHBDL2 Antibody, FITC conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) RHBDL2 Polyclonal antibody
Uniprot No.：

Q9NX52
基因名：

RHBDL2
別名：

RHBDL2 antibody; Rhomboid-related protein 2 antibody; RRP2 antibody; EC 3.4.21.105 antibody; Rhomboid-like protein 2) [Cleaved into: Rhomboid-related protein 2 antibody; N-terminal fragment antibody; NTF); Rhomboid-related protein 2 antibody; C-terminal fragment antibody; CTF)] antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Rhomboid-related protein 2 protein (12-132AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3.
基因功能參考文獻：
1. Thrombomodulin and RHBDL2 are upregulated in human HaCaT cells stimulated by scratch wounds; furthermore, increased solulbe thrombomodulin was found in culture medium. PMID: 21833011
2. RHBDL2 cleaves epidermal growth factor just outside its transmembrane domain, thereby facilitating its secretion and triggering activation of the epidermal growth factor receptor. PMID: 21494248
3. Substrate specificity of RHBDL2 intramembrane protease is governed by helix-breaking residues in the transmembrane domain. PMID: 12820957
4. Here, the authors show that RHBDL2 is produced as a proenzyme and that the processing of RHBDL2 is required for its cellular protease activity. PMID: 19850051
5. The encoded protein is thought to release soluble growth factors by proteolytic cleavage of certain membrane-bound substrates, including ephrin B2 and ephrin B3. PMID: 15047175
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亞細胞定位：

[Rhomboid-related protein 2, C-terminal fragment]: Cell membrane; Multi-pass membrane protein.
蛋白家族：

Peptidase S54 family
數據庫鏈接：

HGNC: 16083

OMIM: 608962

KEGG: hsa:54933

STRING: 9606.ENSP00000289248

UniGene: Hs.524626

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