RGS7 Antibody

中文名稱：

RGS7兔多克隆抗體
貨號：

CSB-PA019659LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA019659LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA019659LA01HU at dilution of 1:100
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) RGS7 Polyclonal antibody
Uniprot No.：

P49802
基因名：

RGS7
別名：

RGS7 antibody; Regulator of G-protein signaling 7 antibody; RGS7 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Regulator of G-protein signaling 7 protein (1-487AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，RGS7 Antibody (CSB-PA019659LA01HU)，的標記方式是Non-conjugated。對于RGS7 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA019659LB01HU	RGS7 Antibody, HRP conjugated	ELISA
FITC	CSB-PA019659LC01HU	RGS7 Antibody, FITC conjugated
Biotin	CSB-PA019659LD01HU	RGS7 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling.
基因功能參考文獻：
1. Results found that RGS7 was mutated in 11% of melanomas with three recurrent mutations (p.R44C, p.E383K and p.R416Q). p.R44C was shown to destabilize the protein due to the loss of an H-bond and salt bridge. RGS7 p.R44C has weaker catalytic activity for its substrate Galphao, thus providing a dual mechanism for its loss of function resulting in increase anchorage-independent growth, migration and invasion of melanoma c... PMID: 29330521
2. Data (including data from studies using transgenic mice) suggest that R7BP-RGS7 heterotrimers interact with Galpha13 to augment signaling pathways in neurons that regulate neurite morphogenesis. (R7BP = RGS7 family binding protein; RGS7 = regulator of G-protein signaling 7 protein; Galpha13 = GTP-binding protein alpha subunit 13) PMID: 28432124
3. R7-binding protein had a strong inhibitory effect on homo-oligomerization of RGS7. PMID: 26895961
4. Fine mapping of the uterine leiomyoma locus on 1q43 close to a lncRNA in the RGS7-FH interval PMID: 26113603
5. New single nucleotide polymorphisms associated with differences in platelets reactivity in patients with type 2 diabetes treated with acetylsalicylic acid: genome-wide association approach and pooled DNA strategy. PMID: 23054467
6. the GAP activity of RGS9-2 showed a strong receptor preference for D2R over MOR. Finally, RGS7 displayed an four times greater GAP activity relative to RGS9-2. PMID: 23857581
7. Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein. PMID: 21343290
8. tumor necrosis factor-alpha regulates the interaction of RGS7 with 14-3-3 PMID: 12077120
9. could play a role in synaptic vesicle exocytosis through its interaction with snapin PMID: 12659861
10. Galpha-regulated plasma membrane localization and palmitoylation of RGS7. PMID: 15496508
11. cytoplasmic RGS7*Gbeta5*R7BP heterotrimers and RGS7*Gbeta5 heterodimers are equivalently inefficient regulators of G protein-coupled receptor signaling relative to plasma membrane-bound heterotrimers bearing palmitoylated R7BP. PMID: 16867977
12. The DEP domain of RGS7 can directly bind to the third intracellular loop of the M3R and attenuate receptor-induced Ca2+ mobilization in a M3 subtype-selective manner. PMID: 19182865
13. cytosolic chaperonin complex-dependent mechanism exists for Gbeta5-RGS7 assembly that utilizes the co-chaperone activity of PhLP1 in a unique way PMID: 19376773
14. common variation within the RGS7 locus may be involved in multiple sclerosis susceptibility. PMID: 19626040
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亞細胞定位：

Cytoplasm, cytosol. Cytoplasm. Cell membrane. Membrane; Peripheral membrane protein; Cytoplasmic side.
數據庫鏈接：

HGNC: 10003

OMIM: 602517

KEGG: hsa:6000

STRING: 9606.ENSP00000355523

UniGene: Hs.655739

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