RGS19 Antibody, HRP conjugated
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中文名稱：RGS19兔多克隆抗體, HRP偶聯
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貨號：CSB-PA019650LB01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) RGS19 Polyclonal antibody
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Uniprot No.：
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基因名：RGS19
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別名：G alpha interacting protein antibody; G protein signalling regulator 19 antibody; G protein; alpha-interacting protein antibody; G-alpha-interacting protein antibody; GAIP antibody; GNAI3IP antibody; Guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein antibody; Regulator of G protein signalling 19 antibody; Regulator of G-protein signaling 19 antibody; RGS19 antibody; RGS19_HUMAN antibody; RGSGAIP antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Regulator of G-protein signaling 19 protein (1-87AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
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基因功能參考文獻：
- RGS19 senses cellular iron availability and is stabilized under iron-depleted conditions, resulting in the induction of a growth-inhibitory signal. PMID: 26116529
- RGS19 may play an important role in controlling the degree of synergism between FGF-1 receptors and 5-HT1A receptors, that may work together to mediate an anti-depressant effect. PMID: 24793302
- Overall methylation levels in the promoter regions of three genes (ALDH1A1, OPRL1 and RGS19) are elevated in subjects who were exposed to childhood adversity. PMID: 23799031
- The RGS19 inhibits Ras signaling through a complex network involving a scaffold protein KSR1 and a nucleoside diphosphate kinase Nm23. PMID: 23416464
- elevated expression of RGS19 can severely disrupt the regulation of mitogen-activated protein kinases by small GTPases PMID: 22045062
- cyclin D1/3 and Cdk6 were upregulated in HEK293 cells overexpressing RGS19, while INK4A and INK4B were reduced PMID: 21705135
- gene structure and transcription regulation PMID: 12507475
- GIPC recruits GAIP (RGS19) to attenuate dopamine D2 receptor signaling PMID: 15356268
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亞細胞定位：Membrane; Lipid-anchor.
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組織特異性：Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.
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數據庫鏈接：
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