Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期:
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.
基因功能參考文獻:
Serum levels of PCT and PSP are promising biomarkers for early diagnosis of pediatric acute osteomyelitis. PMID: 29091592
PSP/reg levels are significantly up-regulated in diabetic kidney disease patients and might be related to renal injury PMID: 28418911
Both univariate and multivariate analysis demonstrated that REG1A expression was associated with OS and PFS, and conducted harmful effects on nasopharyngeal carcinoma progression and survival. This study suggested that REG1A expression could serve as an independent adverse factor for survival in nasopharyngeal carcinoma. PMID: 29162157
Reg I may play a role in the maintenance of mucosal barrier function by inducing tight junction proteins such as claudins 3 and 4. PMID: 27055226
the prognostic value of procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), and pancreatic stone protein (PSP) in children with sepsis, was investigated. PMID: 28358790
REG1alpha was overexpressed in bladder cancer tissues compared with adjacent normal samples. Downregulation of REG1alpha expression in urothelial bladder cancer can reduce tumor growth, migration, invasion and angiogenesis. PMID: 28209239
REG-I is expressed in head and neck squamous cell carcinoma and is associated with a longer survival status. PMID: 27539087
We have established a novel, three-protein biomarker panel that is able to detect patients with early-stage pancreatic cancer in urine specimens:LYVE-1, REG1A, and TFF1 were selected as candidate biomarkers PMID: 26240291
post-operative serum PSP levels were significantly associated with the presence of infection in both the on-pump and off-pump setting. PMID: 25793700
REG Ialpha protein may play a role in angiogenesis during progression of gastric cancer PMID: 25813126
PSP/reg is significantly up-regulated in T2DM patients, and PSP/reg levels are related to the duration of diabetes. PMID: 25234740
the expression of REG Ialpha and REG Ibeta may be upregulated in human beta cells under inflammatory conditions through the JAK/STAT pathway PMID: 25767811
Collectively, these findings suggest that REG Ialpha activates c-Jun via the JNK and ERK pathway, thereby enhancing radiosensitivity PMID: 25656613
Pancreactic stone protein levels were able to diagnose sepsis in patients admitted to intensive care units. PMID: 23531337
PSP/reg levels were significantly higher in patients with a PELOD score of 12 or higher or in those with multiple organ dysfunction syndrome. Patients who died tended to have higher PSP/reg levels. PMID: 24594294
REG Ialpha overexpression is a characteristic ofsessile serrated adenoma/polyps of the colon, which appears to reflect aberration of crypt cell compartmentalization. PMID: 24225137
The effects of REG IA on AD and SCC cells were different in the in vitro study, and a correlation between REG IA expression and patient prognosis was noted in the in vivo study PMID: 24065141
Reduced REG1A expression is associated with chemosensitivity in advanced thoracic esophageal squamous cell carcinoma. PMID: 23645481
PSP/reg and CRP are differentially regulated by HNF1A and HNF4A in maturity-onset diabetes of the young PMID: 23803251
Immunohistochemistry against known cell-type markers on serial sections has localised the expression of REGs to metaplastic Paneth cells (REG1A, REG1B and REG3A) and enteroendocrine cells (REG4), with a marked expansion of expression during inflammation. PMID: 23519454
Reg family proteins stimulate pancreatic beta cell proliferation. PMID: 24055447
Autoimmunity to REG Ialpha might play a role in the degeneration of minor salivary gland ductal epithelial cells in primary Sjogren's syndrome. PMID: 23701206
Regenerating gene (REG) 1 alpha promotes pannus progression in patients with rheumatoid arthritis. PMID: 22203215
REG 1A and REG 1B were upregulated during amebiasis and may function to protect the intestinal epithelium from parasite-induced apoptosis. PMID: 21586335
Regenerating islet-derived 1alpha (Reg-1alpha) protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin Tumor-like 3 (EXTL3) receptor. PMID: 22158612
Regenerating I protein was highly expressed in pure seminoma and in placental-like alkaline phosphatase-positive seminiferous tubules with in situ carcinoma. PMID: 21683984
found a significant increase in REG Ialpha in the sera of celiac disease patients when compared with controls PMID: 21867979
ELISA showed that the serum level of REG1alpha was significantly higher in patients with pancreatic cancer than it was in the normal controls. PMID: 21691750
Raised serum Reg1alpha protein in type 1 and type 2 diabetes and anti-Reg1alpha antibodies in type 1 diabetes, are reported. PMID: 20972946
Upregulation of REG Ialpha accelerates tumor progression in pancreatic cancer with diabetes. PMID: 20099282
REG Ialpha protein may have a pathophysiological role as a biological mediator for immune cell-derived IL-22 in the ulcerative colitis mucosa. PMID: 20065946
This finding suggests that REG I may act through IL-6 to exert effects on squamous esophageal cancer cell biology. PMID: 20056108
did not find any association between abnormalities of either reg1 alpha or reg1 beta gene with type 1 diabetes mellitus, fibrocalculous pancreatopathy, or type 2 diabetes mellitus PMID: 11796176
Characterization, structural analysis and putative functions. Review. PMID: 12369899
REG expression was reported to be an independent predictor of overall gastric adenocarcinoma patient survival PMID: 15022278
Reg I alpha protein may play a role in the development of gastric cancers PMID: 15166487
Reg I was observed not only in pancreatic acinar cells but also in the duct-like cells and dilated duct cells. Reg I expression was linked to acinar cell dedifferentiation. PMID: 15211106
Analysis of the protein in the bile of patients with pancreaticobiliary maljunction/ choledochal cysts PMID: 15628732
REG Ialpha gene is inducible by cytokine stimulation and its gene product may function as a mitogenic and/or an antiapoptotic factor in the development of early gastric cancer. PMID: 15765400
Damaged heart may be a target for Reg action, and Reg may protect against acute heart stress. PMID: 15778284
Polymorphisms in reg1alpha gene, including the regulatory variants singly or in combination with the known mutations in SPINK1 and/or CTSB genes, are not associated with tropical calcific pancreatitis. PMID: 17990360
REG Ialpha protein mediated the anti-apoptotic effects of STAT3 signaling in gastric cancer cells by enhancing Akt activation, Bad phosphorylation and Bcl-xL expression PMID: 18024479
in patients treated with chemoradiotherapy, 8 of 23 REG I-positive patients showed complete responses to chemoradiotherapy; only 1 of 19 REG I-negatives did so; survival rate among REG I-positive patients was significantly better than REG I-negatives PMID: 18259819
REG expression in Barrett's esophagus. Expression of REG Ialpha was more frequently observed in patients who showed squamous re-epithelialization of Barrett's esophagus at biopsy sites. PMID: 18289358
REG1A is prognostic molecular marker associated with peritoneal carcinomatosis in colorectal cancer and is significantly raised in peritumoral normal tissue compared to mucosa from healthy individuals, suggesting a molecular field effect of secreted REG1A PMID: 18452172
The expression of the REG1A gene is closely related to the infiltrating property of primary gastric carcinoma. PMID: 18630596
Overexpression of REG1A is associated with breast cancer. PMID: 18781363
REG1A enhances chemo- and radiosensitivity in squamous cell esophageal cancer cells. PMID: 19032369
Expression of REG Ialpha but not REG IV was an independent predictor of poor outcome in patients with gastric cancer. PMID: 19329938
The expression of REG gene is closely related to the carcinoma invasiveness of gastric neoplasms. PMID: 14508825
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亞細胞定位:
Secreted.
組織特異性:
In pancreatic acinar cells and, in lower levels, in brain. Enhanced expression of PSP-related transcripts and intraneuronal accumulation of PSP-like proteins is found in brain from Alzheimer disease and Down syndrome patients.