RASGRP3 Antibody
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中文名稱：RASGRP3兔多克隆抗體
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貨號：CSB-PA808539ESR2HU
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規格：￥440
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) RASGRP3 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：Calcium and DAG-regulated guanine nucleotide exchange factor III antibody; Grp3 antibody; GRP3_HUMAN antibody; Guanine nucleotide exchange factor for Rap1 antibody; Kiaa0846 antibody; RAS guanyl releasing protein 3 (calcium and DAG regulated) antibody; RAS guanyl releasing protein 3 calcium and DAG regualated guanine nucleotide exchange factor iii antibody; Ras guanyl-releasing protein 3 antibody; RASGRP3 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Ras guanyl-releasing protein 3 protein (541-690AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Guanine nucleotide exchange factor (GEF) for Ras and Rap1.
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基因功能參考文獻：
- In conclusion, these findings provide a new insight into the upregulation of RasGRP3 involved in Notch pathway activation in the development of esophageal squamous cell carcinoma , especially under nutrient deprivation. PMID: 29048643
- these data show that RasGRP3 exerts its oncogenic effect in papillary thyroid cancer through Akt-mediated MDM2 activation. PMID: 28864115
- RasGRP3 mediates ERK MAPK pathway activation in GNAQ mutant uveal melanoma. PMID: 28486107
- Knockdown of RasGRP3 inhibited proliferation in prostate neoplasms. PMID: 24418912
- Ras activator RasGRP3 may have a role in the pathological behavior of breast cancer cells and may constitute a therapeutic target for human breast cancer. PMID: 24779681
- The identification of the role of RasGRP3 in melanoma highlights its importance, as a Ras activator, in the phosphoinositide signaling pathway in human melanoma. PMID: 21602881
- Significant associations were found for the single nucleotide polymorphism rs13385731 of RasGRP3 with malar rash, discoid rash, and antinuclear antibody in patients with systemic lupus erythematosus PMID: 20516000
- RasGRP3 contributes to the malignant phenotype of prostate cancer cells and may constitute a novel therapeutic target for human prostate cancer. PMID: 20876802
- A vascular gene trap screen defines RASGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters. PMID: 15572660
- studies support the hypothesis that RasGRP phosphorylation by PKC is a mechanism that integrates DAG signaling systems in T and B cells PMID: 15657177
- dynein light chain 1 represents a novel anchoring protein for RasGRP3 that may regulate subcellular localization of the exchange factor PMID: 17012239
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蛋白家族：RASGRP family
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數據庫鏈接：
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