RASGRF1 Antibody

說明書

中文名稱：

RASGRF1兔多克隆抗體
貨號：

CSB-PA006353
規(guī)格：

￥1090
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

Q13972
基因名：

RASGRF1
別名：

CDC25 antibody; CDC25L antibody; GNRP antibody; GRF1 antibody; GRF55 antibody; Guanine nucleotide exchange factor antibody; Guanine nucleotide releasing factor 55 kD antibody; Guanine nucleotide releasing protein antibody; guanine nucleotide-releasing factor 1 antibody; Guanine nucleotide-releasing protein antibody; H GRF55 antibody; HGRF55 antibody; PP13187 antibody; Ras protein specific guanine nucleotide releasing factor 1 antibody; Ras specific guanine nucleotide releasing factor antibody; Ras specific guanine nucleotide releasing factor CDC25 homolog antibody; Ras specific nucleotide exchange factor CDC25 antibody; Ras-GRF1 antibody; Ras-specific guanine nucleotide-releasing factor 1 antibody; Ras-specific nucleotide exchange factor CDC25 antibody; RASGRF1 antibody; RGRF1_HUMAN antibody
宿主：

Rabbit
反應(yīng)種屬：

Mouse,Rat
免疫原：

Synthesized peptide derived from Mouse Ras-GRF1 around the non-phosphorylation site of S916.
免疫原種屬：

Mus musculus (Mouse)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:5000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Promotes the exchange of Ras-bound GDP by GTP.
基因功能參考文獻：
1. Low RASGRF1 expression due to hypermethylation is associated with Colorectal Cancer. PMID: 29530990
2. Our studies have shown that the heritability of myopia makes 66.4% in Lithuania. We detected significant associations between the combinations of GJD2 CC and RASGRF1 GT and odds ratio of developing myopia. PMID: 29793445
3. genetic variants in BICC1 and RASGRF1 are closely associated with high myopia, which appears to be a potential candidate for high myopia in Chinese Han population. PMID: 29044055
4. Endoplasmic reticulum stress triggers a localized signaling module on the ER surface involving Nox4-dependent calcium mobilization, which directs local Ras activation through ER-associated, calcium-responsive RasGRF. PMID: 27856453
5. Data show that microRNA miR-137 directly recognized the 3'-UTR (3'-untranslated region) of the RASGRF1 (Ras protein-specific guanine nucleotide-releasing factor 1) transcript and regulated RASGRF1 expression. PMID: 26440052
6. Impaired RASGRF1/ERK-mediated GM-CSF response characterizes CARD9 deficiency in French-Canadians. PMID: 26521038
7. Carriers of the rs8027411 G allele in the RASGRF1 gene may be at a lower risk of high myopia in Chinese and Japanese populations. (Meta-analysis) PMID: 26644762
8. Rasgrf-1 is a novel GEF protein that has a role in BCR signaling and its overexpression further activates the Ras/Erk/MAPK pathway in CLL specimens. PMID: 24597981
9. In this study, there was no association of the analyzed SNPs located in RASGRF1. GJD2, and ACTC1 with pathological myopia. PMID: 23834555
10. CARD9 regulates H-Ras activation by linking Ras-GRF1 to H-Ras, which mediates Dectin-1-induced extracellular signal-regulated protein kinase (ERK) activation and proinflammatory responses when stimulated by their ligands. PMID: 25267792
11. ZIC2 and RASGRF1 are susceptibility genes, not only for common myopia, but also for high myopia. PMID: 24150758
12. Decreased expression of Ras-GRF1 could be involved in the pathogenesis of human temporal lobe epilepsy. PMID: 23200899
13. Aberrant methylation of RASGRF1 is associated with an epigenetic field defect and increased risk of gastric cancer. PMID: 22961779
14. RasGRF1 plays an important role in alveolar rhabdomyosarcoma pathogenesis PMID: 22752028
15. Demonstrate a role for RasGRF1/2 as negative regulators of Cdc42 activation, suppressing tumor cell movement, cytoskeletal dynamics and cell transformation. PMID: 21685891
16. Single Nucleotide Polymorphisms in RASGRF1 is associated with refractive errors and myopia. PMID: 20835236
17. Farnesylated or geranylgeranylated TC21 can be activated by RasGRF1 due to its pleckstrin homology 1 domain, by a mechanism independent of localization & of its ability to associate to membranes. PMID: 19692568
18. RasGRF family exchange factors, both endogenous and ectopically expressed, are present in the endoplasmic reticulum but not in the Golgi complex PMID: 14749369
19. Taken together our results demonstrate that U2AF35a is essential for HeLa cell division and suggest a novel role for both U2AF35 protein isoforms as regulators of alternative splicing of a specific subset of genes. PMID: 16855028
20. Vitamin K3 inhibitor H32 differentially inhibited growth of normal and liver tumor cells by preferentially inhibiting the actions of Cdc25 phosphatases PMID: 16969075
21. Rasgrf1 transgenic repeats serve at least two functions: first, to establish Rasgrf1 DNA methylation in the male germ line, and second, to resist global demethylation in the preimplantation embryo. PMID: 17030618
22. zoledronate induces DNA damage and S phase arrest, accompanied by activation of the ATM/Chk1/cdc25 pathway in a human osteosarcoma cell line PMID: 17611684
23. Enhanced expression and post-translational modification of RasGRF1 contributes to MMP-3 production in RA PMID: 19678938
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數(shù)據(jù)庫鏈接：

HGNC: 9875

OMIM: 606600

KEGG: hsa:5923

STRING: 9606.ENSP00000405963

UniGene: Hs.459035

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