RASEF Antibody

說明書

產(chǎn)品詳情

Uniprot No.：

Q8IZ41
基因名：

RASEF
別名：

RASEF antibody; RAB45 antibody; Ras and EF-hand domain-containing protein antibody; Ras-related protein Rab-45 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse
免疫原：

Human RASEF
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Binds predominantly GDP, and also GTP. Acts as a dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules.
基因功能參考文獻：
1. Near-genomewide RNAi screening for regulators of BRAF(V600E) -induced senescence identifies RASEF, a gene epigenetically silenced in melanoma. PMID: 24703243
2. overexpression of RAB45 increased the phosphorylation levels of p38, resulting in the induction of apoptosis and inhibition of proliferation of CML progenitor cells PMID: 21890458
3. Homozygosity, in combination with methylation, appears to be the mechanism targeting RASEF in uveal melanoma, and allelic imbalance at this locus supports a TSG role for RASEF. PMID: 18385040
亞細胞定位：

Cytoplasm, perinuclear region.
蛋白家族：

Small GTPase superfamily, Rab family
組織特異性：

Down-regulated in cutaneous melanoma cells but not in breast cancer cells.
數(shù)據(jù)庫鏈接：

HGNC: 26464

OMIM: 611344

KEGG: hsa:158158

STRING: 9606.ENSP00000365630

UniGene: Hs.129136

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