RASAL1 Antibody
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中文名稱：RASAL1兔多克隆抗體
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貨號(hào)：CSB-PA019351LA01HU
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規(guī)格：￥440
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圖片：
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Immunofluorescence staining of MCF-7 cells with CSB-PA019351LA01HU at 1:105, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) RASAL1 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：GAP1 like protein antibody; MRASAL antibody; RAS GTPase activating protein like antibody; RAS protein activator like 1 (GAP1 like) antibody; RAS protein activator like 1 antibody; RASAL antibody; Rasal1 antibody; rasGAP activating like protein 1 antibody; RasGAP-activating-like protein 1 antibody; RASGAP1 LIKE antibody; RASL1_HUMAN antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human RasGAP-activating-like protein 1 protein (698-804AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
本頁(yè)面中的產(chǎn)品，RASAL1 Antibody (CSB-PA019351LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于RASAL1 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, IF
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推薦稀釋比：
Application Recommended Dilution IF 1:50-1:200 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
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靶點(diǎn)詳情
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功能：Probable inhibitory regulator of the Ras-cyclic AMP pathway. Plays a role in dendrite formation by melanocytes.
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基因功能參考文獻(xiàn)：
- Domain topology of human Rasal PMID: 28885980
- HIF1alpha and transforming growth factor (TGF)/SMAD signalling pathways synergistically regulate hypoxia-induced endothelial-to-mesenchymal transition through both DNMT3a-mediated hypermethylation of RASAL1 promoter and direct SNAIL induction. PMID: 27012941
- RASAL1 role in in sorafenib-resistance of liver cancer cells PMID: 27878301
- our study showed significantly longer overall survival times for oesophagogastric adenocarcinoma patients without RASAL1 expression PMID: 28011578
- DNA methylation, TGFbeta1 and RASAL1 appear to have an interacting relationship. PMID: 27124111
- Report a new subtype of high-grade mandibular osteosarcoma with RASAL1/MDM2 amplification. PMID: 26997440
- These findings suggest that Ebp1 suppressed thyroid cancer cell lines by upregulating RASRAL expression. PMID: 26008146
- large chromosome 12 rearrangement, spanning MDM2 and RASAL1, is the first recurrent molecular abnormality to be reported in juvenile ossifying fibroma PMID: 24925056
- Loss of RASAL1 expression is associated with gastric carcinogenesis. PMID: 25735335
- Transcriptional suppression of RASAL1 through aberrant promoter methylation contributes to endothelial-mesenchymal transition and ultimately to progression of cardiac fibrosis. PMID: 25616414
- Promoter hypermethylation of the RASAL1 gene was detected in MKN-28, SGC-790l and BGC-823 cancer cells. PMID: 24377515
- It is a tumor suppressor gene which influences the proliferation and invasion of gastric cancer by regulating RAS/ERK signaling pathway. PMID: 24531877
- Germline RASAL1 alterations are uncommon in patients with Cowden syndrome but may not be infrequent in patients with apparently sporadic follicular-variant papillary thyroid cancer. PMID: 24712574
- We identified RASAL1 as a major tumor suppressor gene that is frequently inactivated by hypermethylation and mutations, providing a new alternative genetic background for thyroid cancer, particularly FTC and ATC. PMID: 24136889
- Hypermethylations of RASAL1 and KLOTHO is associated with renal dysfunction in a Chinese population environmentally exposed to cadmium PMID: 23665422
- decreased RASAL1 expression is a characteristic of gastric cancer and regulated by epigenetic mechanisms PMID: 22825043
- Ras GTPase activating (RasGAP) activity of the dual specificity GAP protein Rasal requires colocalization and C2 domain binding to lipid membranes. PMID: 23251034
- Reduced expression of RAS protein activator like-1 is associated with gastric cancer. PMID: 20473946
- Galpha and Gbeta gamma require distinct Src-dependent pathways for its activation PMID: 12221082
- RASAL preservs of Ca2+ frequency information PMID: 16009725
- RASAL constitutes a tumor suppressor gene and therefore further emphasized the importance of Ca(2+) in the regulation of Ras signaling and has established that deregulation of this pathway is an important step in Ras-mediated tumorigenesis PMID: 17640920
- Decreased expression of the RAS-GTPase activating protein RASAL1 is associated with colorectal tumor progression. PMID: 18992247
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組織特異性：Highly expressed in thyroid and adrenal medulla, lower expression in brain, spinal cord and trachea. Expressed in melanocytes.
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數(shù)據(jù)庫(kù)鏈接：
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