RARG Antibody, Biotin conjugated

說明書

中文名稱：

RARG兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA019340LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) RARG Polyclonal antibody
Uniprot No.：

P13631
基因名：

RARG
別名：

NR1B3 antibody; Nuclear receptor subfamily 1 group B member 3 antibody; RAR gamma antibody; RAR gamma isoform 2 antibody; RAR gamma2 antibody; RAR-gamma antibody; RARC antibody; Rarg antibody; RARG_HUMAN antibody; retinoic acid nuclear receptor gamma variant 1 antibody; retinoic acid nuclear receptor gamma variant 2 antibody; Retinoic acid receptor gamma antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Retinoic acid receptor gamma protein (13-87AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function.
基因功能參考文獻：
1. Study reports that retinoic acid receptor-gamma (RARgamma) is a negative regulator of p53 signaling and thus extend the oncogenic potential of RARgamma to a new role in controlling the balance between AKT and p53. PMID: 28336971
2. the cytoplasmic retinoic acid receptor gamma (RARgamma) controls receptor-interacting protein kinase 1 (RIP1)-initiated cell death when cellular inhibitor of apoptosis (cIAP) activity is blocked. PMID: 28871172
3. Results show that RARgamma expression is significantly upregulated in human hepatocellular carcinoma (HCC) tissues and demonstrate that RARgamma could promote HCC invasion and metastasis by regulating E-cadherin reduction. PMID: 27756432
4. Our study is the first to report that treatment with a RARgamma specific agonist augments cellular adhesion to alpha5beta1 integrin substrates, increases cell surface levels of the beta1 integrin subunit, and dampens cellular proliferation in a time and concentration dependent manner in a human erythroleukemia cell line PMID: 28552962
5. Loss of RARG expression is associated with Colorectal Tumorigenesis and Metastasis. PMID: 27325643
6. RARgamma might serve as a potential therapeutic target for chemoresistant colorectal cancer patients. PMID: 28272990
7. A nonsynonymous variant in RARG is highly associated with anthracycline-induced cardiotoxicity in childhood cancers. PMID: 26237429
8. deregulation of the retinoid/rexinoid signaling pathway has a major role and may represent a potential therapeutic target for NUP98-RARG-mediated transformation PMID: 25510432
9. RARgamma in concert with ATRA regulates protein levels of CDK1 and its subcellular localization. PMID: 23518499
10. RARG plays an important role in the proliferation, metastasis, and chemoresistance of cholangiocarcinoma through simultaneous activation of the Akt/NF-kappaB and Wnt/beta-catenin pathways. PMID: 23798555
11. Low RARgamma expression is associated with advanced gastric cancer. PMID: 22901127
12. Evidence that the retinoic acid receptor gamma plays a major role in the regulation of the human prostatic transglutaminase gene. PMID: 22362749
13. findings demonstrate that signaling through RARs has critical roles in molecular reprogramming and that the synergistic interaction between Rarg and Lrh1 directs reprogramming toward ground-state pluripotency PMID: 21990348
14. results suggest that a RARgamma-dependent functional crosstalk is present between the retinoic acid and BMP2 signaling to induce osteogenic transdifferentiation in myoblastic C2C12 cells PMID: 21401418
15. Microbiota are required for the generation of both IL-17-positive and Foxp3-positive, retinoic acid-related orphan receptor gamma-positive transgenic T cell subsets in the intestinal lamina propria. PMID: 21178008
16. PARgamma expressions are decreased in PBMC and SWAT of obese subjects in weight gain. PMID: 20387030
17. Retinoic acid receptor gamma 2 could specifically interact with vitamin D response elements, either in the presence or absence of the vitamin D receptor. PMID: 20420906
18. Retinoid signaling is attenuated by retinoic acid-induced proteasome-mediated degradation of RARG in human keratocytes. PMID: 11855864
19. Retinoids cause apoptosis in pancreatic cancer cells via activation of RAR-gamma and altered expression of Bcl-2/Bax. PMID: 12189556
20. The 1.4 A resolution crystal structure of the ligand binding domain of the retinoic acid receptor RARgamma complexed with the retinoid SR11254 reveals several types of C-H...O hydrogen bonds PMID: 12220491
21. Present throughout the epithelium with minimal nuclear accumulation. Increased in basal and luminal epithelial nuclei in glands with benign prostatic hyperplasia. PMID: 12399530
22. RARgamma interact only weakly with SMRT. PMID: 12554770
23. In a 9-cis retinoic acid-dependent fashion in cells in vitro, retinoic acid receptor isoform gamma stimulates the expression of reporter constructs containing the site that binds aldehyde dehydrogenase-2. PMID: 14691372
24. Tazarotene is a prodrug selective for RARbeta/gamma, thereby motivating interest in determining whether tazarotene might activate putative tumor suppressor activity. PMID: 15383624
25. phosphorylation of the AF-1 domain controls RARgamma-mediated transcription through triggering the dissociation of vinexin beta PMID: 15734736
26. study elucidated a nongenomic extranuclear signal mediated by the RAR-SRC interaction that is negatively regulated by CSK and is required for RA-induced neuronal differentiation PMID: 17325034
27. analysis to determine directly whether PML-RAR, like PML-RAR, is able to induce APL PMID: 18685608
28. The first 2250 bp of the HAS2 promoter contain three response elements (REs) for the transcription factor CREB1 as well as two REs for the nuclear receptor RAR PMID: 19416972
29. the subcellular localization of RARgamma is regulated by complex interactions among ligand binding, receptor phosphorylation, and receptor dimerizations PMID: 19416983
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亞細胞定位：

Nucleus. Cytoplasm.
蛋白家族：

Nuclear hormone receptor family, NR1 subfamily
組織特異性：

Expressed in aortic endothelial cells (at protein level).
數據庫鏈接：

HGNC: 9866

OMIM: 180190

KEGG: hsa:5916

STRING: 9606.ENSP00000377947

UniGene: Hs.1497

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