RAPGEF4 Antibody

說(shuō)明書(shū)

中文名稱：

RAPGEF4兔多克隆抗體
貨號(hào)：

CSB-PA019332GA01HU
規(guī)格：

￥3,900
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

Uniprot No.：

Q8WZA2
基因名：

RAPGEF4
別名：

CAMP GEFII antibody; cAMP regulated guanine nucleotide exchange factor II antibody; cAMP-GEFII antibody; cAMP-regulated guanine nucleotide exchange factor II antibody; CAMPGEFII antibody; CGEF 2 antibody; CGEF2 antibody; Epac 2 antibody; EPAC2 antibody; Exchange factor directly activated by cAMP 2 antibody; Exchange protein directly activated by cAMP 2 antibody; Nbla00496 antibody; Putative protein product of Nbla00496 antibody; Rap guanine nucleotide exchange factor (GEF) 4 antibody; Rap guanine nucleotide exchange factor 4 antibody; RAPGEF 4 antibody; Rapgef4 antibody; RPGF4_HUMAN antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human RAPGEF4
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.
基因功能參考文獻(xiàn)：
1. Study identifies Epac2-Rap1 signaling as a novel feedback mechanism in the heart, which controls mitochondrial reactive oxygen species production. PMID: 27649969
2. rs17746510, one of the three single-nucleotide polymorphisms (SNPs) in RAPGEF4 associated with cognitive decline in Chinese Alzheimer's disease (AD) patients, was significantly correlated with apathy and mood disturbance PMID: 27598965
3. Data show that Epac2 is activated by cAMP and changes its structure. It is involved in cAMP-mediated signal transduction through activation of the Ras-like small GTPase and is expressed mainly in brain, neuroendocrine and endocrine tissues. [review] PMID: 26390815
4. CALR regulated by EPAC2 in endometrial glandular epithelial cells is critical for the expression of LIF and PTGS2-mediated production of PGE2 through cAMP signaling. PMID: 25378661
5. Follow-up replication analyses in up to an additional 21,345 participants identified three new fasting plasma glucose loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. PMID: 25187374
6. EPAC2-mediated CRT expression is essential for the functional and morphological differentiation of endometrial stromal cells into decidual cells PMID: 24169561
7. Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry PMID: 21454623
8. An important time-limited role is identified for hippocampal Epac2 signaling in cognition, opening new avenues to investigate the molecular mechanisms underlying memory retrieval. PMID: 19739231
9. Epac2 & Epac1 signaling pathways may be associated with cAMP-mediated functional differentiation and syncytialization of trophoblasts. Expression of Epac2 & Epac 1 in placenta at different stages was investigated. PMID: 20663796
10. Studies demonstrate the occurrence of the EPAC2 splicing variant EPAC2B in adrenocortical cancer cells and reveal the involvement of EPAC2B in cAMP-induced effects on cytoskeleton integrity and cell migration. PMID: 20233795
11. Mutations in the hinge of Epac can uncouple cAMP binding from its exchange activity. PMID: 12469113
12. variants were present in five families, where they segregate with the autistic phenotype. PMID: 14593429
13. Epac2 signaling plays a stimulatory role in pancreatic and intestinal endocrine cells, including proglucagon transcription and glucagon and GLP-1 production. PMID: 18854429
14. Substitution of the conserved phenylalanine 435 with glycine facilitates the hinge bending and leads to a constitutively active Epac2 capable of stimulating nucleotide exchange in the absence of cAMP. PMID: 19553663
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亞細(xì)胞定位：

Cytoplasm. Membrane; Peripheral membrane protein.
組織特異性：

Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 16626

OMIM: 606058

KEGG: hsa:11069

STRING: 9606.ENSP00000380271

UniGene: Hs.470646

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