RANGAP1 Antibody
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中文名稱：RANGAP1兔多克隆抗體
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貨號：CSB-PA019318GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：RANGAP1
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別名：Fug 1 antibody; Fug1 antibody; GTPase-activating protein, RAN, 1 antibody; KIAA1835 antibody; MGC20266 antibody; OTTHUMP00000028918 antibody; OTTHUMP00000198755 antibody; OTTHUMP00000198756 antibody; OTTHUMP00000198757 antibody; OTTHUMP00000198758 antibody; RAGP1_HUMAN antibody; Ran 1 antibody; RAN GTPase activating protein 1 antibody; Ran GTPase-activating protein 1 antibody; Ran1 antibody; RANGAP 1 antibody; RANGAP antibody; RanGAP1 antibody; SD antibody; Segregation distorter homolog antibody; Segregation distortion antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human RANGAP1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC,IF
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：GTPase activator for RAN. Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export. Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export.
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基因功能參考文獻：
- RanGAP1 upregulation is associated with drug resistance in Chronic Myeloid Leukemia. PMID: 27228340
- Abnormal localization of RanGAP1 was found in cortex of Huntington's disease patients. PMID: 28384474
- our results elucidate that RanGAP1 is actively transported between the nuclear and cytoplasmic compartments, and that the cytoplasmic and NPC localization of RanGAP1 is dependent on CRM1-mediated nuclear export. PMID: 26506250
- immune cell adaptor SLP-76 binds directly to SUMO-RanGAP1 of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 and NF-kappaB p65 nuclear entry in T cells PMID: 26321253
- Differentiation of human coronary artery smooth muscle cell to a contractile phenotype by stepwise serum depletion leads to significant reduction of RanGAP1 protein levels. PMID: 24988324
- Analysis of the dynamics of E2(Ubc9)-SUMO-Target(RanGAP1) in the absence and presence of E3(RanBP2) revealed that two different allosteric sites regulate the ligase activity. PMID: 21216249
- the RanGAP1 consensus sumoylation site and SUMO-1 C terminus are both conformationally flexible PMID: 15355965
- the 3.0-A crystal structure of a four-protein complex of Ubc9, a Nup358/RanBP2 E3 ligase domain (IR1-M) and SUMO-1 conjugated to the carboxy-terminal domain of RanGAP1 PMID: 15931224
- RanGAP1 is phosphorylated on Ser-358 in vivo & in vitro. Phosphorylated RanGAP1, but not a mutant at 358S, formed a stable ternary complex with Ran and RanBP1 in vivo, suggesting that its 358S phosphorylation affects the Ran system. PMID: 16428860
- The results of this study strengthen the conclusion that mel-18 functions as an anti-SUMO E3 factor, and extend its targets to include regulation of the sumoylation of the important cellular protein RanGAP1. PMID: 18706886
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亞細胞定位：Cytoplasm. Nucleus, nucleoplasm. Nucleus envelope. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle.
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蛋白家族：RNA1 family
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組織特異性：Highly expressed in brain, thymus and testis.
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數據庫鏈接：
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