RABL3 Antibody

說明書

產品詳情

Uniprot No.：

Q5HYI8
基因名：

RABL3
別名：

RAB member of RAS oncogene family like 3 antibody; Rab-like protein 3 antibody; RABL3 antibody; RABL3_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human RABL3
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Required for KRAS signaling regulation and modulation of cell proliferation. Regulator of KRAS prenylation, and probably prenylation of other small GTPases. Required for lymphocyte development and function. Not required for myeloid cell development.
基因功能參考文獻：
1. Hepatocellular carcinoma patients with positive expression for both Rabl3 and Cullin7 had a remarkably shorter survival time compared with patients with negative expression for both proteins. PMID: 28739496
2. Our studies suggest that the Rabl3 is a valuable marker of hepatocellular carcinoma progression and that the overexpression of Rabl3 plays an important role in the development and pathogenesis of hepatocellular carcinoma. PMID: 28443498
3. We examine the correlation between the expression level of Rabl3 and survival of non-small cell lung cancer (NSCLC) patients in three independent cohorts containing 484 patients. We found high expression of Rabl3 might inhibit cell death in non-small cell lung cancer via repression of MAPK8/9/10-mediated autophagy PMID: 27164297
4. Rabl3 can be considered as a novel candidate in the control of tumorigenesis and as a new target for anticancer treatment. PMID: 20596630
蛋白家族：

Small GTPase superfamily, Rab family
數據庫鏈接：

HGNC: 18072

KEGG: hsa:285282

STRING: 9606.ENSP00000273375

UniGene: Hs.444360

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