RAB6A Antibody
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中文名稱：RAB6A兔多克隆抗體
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貨號：CSB-PA019216GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：RAB6A
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別名：GTP binding protein RAB6A' antibody; GTP binding protein RAB6B antibody; Oncogene RAB6 antibody; Rab 6 antibody; Rab GTPase antibody; Rab-6 antibody; RAB6 antibody; RAB6 member RAS oncogene family antibody; RAB6A antibody; RAB6A member RAS oncogene family antibody; Rab6A variant 3 antibody; RAB6A' antibody; RAB6A_HUMAN antibody; RAB6B antibody; Ras related protein Rab 6A antibody; Ras-related protein Rab-6A antibody; RCO4 3 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human RAB6A
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Involved in COPI-independent retrograde transport from the Golgi to the ER.
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基因功能參考文獻：
- Ectopic expression of an N-terminal-truncated ARHGEF10 mutant led to the generation of large vesicle-like structures containing both Rab6 and Rab8. PMID: 27550519
- Rab6A binding to KIF1C's motor domain represents an entirely new mode of regulation for a kinesin motor, and likely has important consequences for KIF1C's cellular functions. PMID: 25821985
- GORAB missense mutation disrupt RAB6 protein binding in genetic skin diseases. PMID: 26000619
- several analyses of vesicular transport demonstrated that Rab6A and BICD2 play crucial roles in Golgi tubule fusion with the endoplasmic reticulum (ER) in brefeldin A (BFA)-treated cells PMID: 25962623
- Data suggest that miR-5100 promotes tumor growth by facilitating the G1/S transition and targeting Rab6. PMID: 25754817
- Data indicate that myosin Va interacted with multiple new Rab subfamilies including Rab6, Rab14 and Rab39B. PMID: 24006491
- Mint1 826 bridges APP to the small GTPase PMID: 23737971
- The presence of an active pool of Rab6 within host cells early during infection is required to support efficient intracellular growth of L. pneumophila. PMID: 23569112
- Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase. PMID: 23091056
- GTP-bound form of Rab6 promotes retrograde trafficking of cav-2 from the Golgi to ER PMID: 22607032
- the crystal structure of the human Rab6A'(Q72L) mutant form at 1.9A resolution is reported. PMID: 22750005
- Rab6 modulates the unfolded protein response (UPR), increased levels inhibit whereas decreased levels augment UPR induction. PMID: 22124028
- Electron tomography reveals Rab6 is essential to the trafficking of trans-Golgi clathrin and COPI-coated vesicles and the maintenance of Golgi cisternal number PMID: 22335553
- Rab6 is required for Rab8A association with exocytotic vesicles. PMID: 21596566
- In contrast to wild-type R6IP1-Rab6 crystals, which took several weeks to grow to full size, the engineered R6IP1 (RPdel)-Rab6 crystals could be grown in a matter of days PMID: 21543860
- The authors found that the small GTPase Rab6 also interacts indirectly with cytomegalovirus pp150 through its interaction with Bicaudal D1. PMID: 21411515
- Data show that Rab6, a Golgi-associated Rab, forms a complex with myosin II, contributes to its localization at the Golgi complex and, unexpectedly, controls the fission of Rab6 vesicles. PMID: 20562865
- recombinant antibodies specific to the GTP-bound conformation of Rab6 were generated and used to locate Rab6; Rab6 was in its GTP-bound conformation on the Golgi apparatus and transport intermediates PMID: 12738866
- Rab6A and Rab6A' regulate microtubule-dependent recycling at the trans-Golgi network PMID: 15483056
- 10 genes were down-regulated following treatment of the T-ALL cells with 0.15 and 1.5 microg/mL of metal ores at 72 h. GTP binding activity, RaB small monomeric GTPase activity, protein transporter activity. PMID: 15747776
- Results show the crystal structure of the GTPase Rab6A in the GTP bound form. PMID: 16332443
- Rab6A' likely regulates the dynamics of the dynein/dynactin complex at the kinetochores and consequently the inactivation of the Mad2-spindle checkpoint. PMID: 16395330
- Results show that Rab6A and Rab6A' perform different functions within the cell and suggests a novel role for Rab6A' as the major Rab6 isoform regulating previously described Rab6-dependent transport pathways. PMID: 16536738
- role of the Rab6 isoforms in retrograde transport of ricin using both oligo- and vector-based RNAi assays PMID: 16683916
- a highly significant correlation between the Rab6 and the UPR marker BiP in Alzheimer disease brains. PMID: 17573808
- These data demonstrate that although Rab6 is not essential for secretion, it controls the organization of exocytosis within the cellular space. PMID: 17681140
- Rab6 regulates distinct Golgi trafficking pathways involving two separate protein complexes: ZW10/RINT-1 and COG. PMID: 17699596
- DYNLRB1 specifically interacts with all three Rab6 isoforms and co-localises at the Golgi. PMID: 18044744
- Data show that iPLA(1)gamma is a novel membrane transport factor that contributes to a specific Golgi-to-ER retrograde pathway distinct from presently characterized COPI- and Rab6-dependent pathways. PMID: 19632984
- Study demonstrates that Golgi recruitment of endogenous GCC185 does not involve Rab6A/A' and Arl1. PMID: 19703403
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亞細胞定位：Golgi apparatus membrane; Lipid-anchor.; [Isoform 1]: Golgi apparatus membrane; Lipid-anchor.; [Isoform 2]: Golgi apparatus membrane; Lipid-anchor.
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蛋白家族：Small GTPase superfamily, Rab family
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組織特異性：Ubiquitous.
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數據庫鏈接：
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