RAB2A Antibody

說明書

中文名稱：

RAB2A兔多克隆抗體
貨號：

CSB-PA226407
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA226407(RAB2A Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 12%SDS-PAGE,Lysate: 40 μg,Lane 1-4: K562 cells, Mouse brain tissue, 231 cells, HepG2 cells,Primary antibody: CSB-PA226407(RAB2A Antibody) at dilution 1/400 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 10 seconds
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P61019
基因名：

RAB2A
別名：

9330148M11Rik antibody; C80220 antibody; GTP binding protein antibody; LHX antibody; OTTMUSP00000004796 antibody; RAB2 antibody; RAB2 member RAS oncogene family antibody; RAB2A antibody; RAB2A; member RAS oncogene family antibody; RAB2A_HUMAN antibody; Ras related protein Rab 2A antibody; RAS-associated protein RAB2 antibody; Ras-related protein Rab-2A antibody; RP23-183L6.1 antibody; Small GTP binding protein RAB2A antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Full length fusion protein
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Required for protein transport from the endoplasmic reticulum to the Golgi complex.
基因功能參考文獻：
1. S100A7 affects cell motility and invasion by regulating the RAB2A-associated MAPK signaling cascades. PMID: 27767088
2. Identify Rab2 as a key factor for autophagic and endocytic cargo delivery to and degradation in lysosomes. PMID: 28483915
3. our data reveal that RAB2A is new critical membrane trafficking players in the regulation of mesenchymal properties of normal and tumorigenic cells and a critical determinant of an invasive, proteolytic mode of BC progression. PMID: 27255086
4. RAB2A variance has effect on the structure and function of the PFC and related cognitive functions. PMID: 26249043
5. This study demonstrated that RAB2A mutation showing the highest statistical significance in Autism and Schizophrenia. PMID: 26938441
6. The immunohistochemistry-based validation using tissue microarray slides in oral squamous cell carcinoma revealed overexpression of the RAB2A and PRDX1 gene in 80 and 68 % of the tested clinical cases, respectively. PMID: 26159854
7. Pin1/Rab2A/Erk drives BCSC expansion and tumorigenicity, suggesting potential drug targets. PMID: 25818297
8. As a result of the translocations, RAB2A-PLAG1, the constitutively active promoter of the partner gene drives the ectopic expression of PLAG1. PMID: 24700772
9. first X-ray crystal structure of RicA to 2.7 A resolution and have quantified the affinity of RicA binding to human Rab2 in its GDP-bound and nucleotide-free forms PMID: 24251537
10. The authors identified a specific interaction between the human small GTPase Rab2 and a Brucella spp. protein named RicA. PMID: 21501366
11. The results of this study provided that RAB2A and SLC38A1, were associated with the density of calbindin-positive neurons and the number of perineuronal oligodendrocytes in psychiatric disorders. PMID: 20308991
12. Rab2 interacts directly with atypical protein kinase C iota/lambda and inhibits aPKCiota/lambda-dependent GADPH phosphorylation PMID: 14570876
13. These data demonstrate that Rab2 and Rab6 differentially influence anterograde transport and signaling of GPCRs. PMID: 17716866
14. ICA69 as a novel Rab2 effector and its role in regulating the early transport of insulin secretory granule proteins PMID: 18187231
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亞細胞定位：

Endoplasmic reticulum-Golgi intermediate compartment membrane; Lipid-anchor. Melanosome. Endoplasmic reticulum membrane; Lipid-anchor. Golgi apparatus membrane; Lipid-anchor. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
蛋白家族：

Small GTPase superfamily, Rab family
數據庫鏈接：

HGNC: 9763

OMIM: 179509

KEGG: hsa:5862

STRING: 9606.ENSP00000262646

UniGene: Hs.369017

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