RAB12 Antibody, Biotin conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) RAB12 Polyclonal antibody
Uniprot No.：

Q6IQ22
基因名：

RAB12
別名：

Putative Ras related protein Rab 12 antibody; RAB12 antibody; RAB12; member RAS oncogene family antibody; RAB12_HUMAN antibody; Ras-related protein Rab-12 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Ras-related protein Rab-12 protein (98-241AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy.
基因功能參考文獻：
1. DENND3 is the exchange factor for the small GTPase Rab12 regulated through an intramolecular interaction PMID: 28249939
2. a novel signaling pathway identified whereby starvation-induced activation of ULK leads to phosphorylation of endogenous DENND3, with subsequent activation of Rab12 and initiation of membrane trafficking events required for autophagy PMID: 25925668
3. findings demonstrate the functional importance of Rab12 for retrograde toxin trafficking PMID: 24703428
亞細胞定位：

Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Lysosome membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane. Cytoplasmic vesicle, autophagosome.
蛋白家族：

Small GTPase superfamily, Rab family
數據庫鏈接：

HGNC: 31332

OMIM: 616448

KEGG: hsa:201475

STRING: 9606.ENSP00000331748

UniGene: Hs.270074

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