Piezo Antibody

^{Rare Species}

說明書

中文名稱：

Piezo Antibody
貨號：

CSB-PA562252XA01DLU
規格：

￥880
圖片：
Western Blot
Positive WB detected in: recombinant protein
All lanes: Piezo Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 42 kDa
Observed band size: 42 kDa
其他：

產品詳情
產品評價
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Drosophila melanogaster (Fruit fly) Piezo Polyclonal antibody
Uniprot No.：

M9MSG8
基因名：

Piezo
別名：

Piezo-type mechanosensitive ion channel component Piezo CG18103
宿主：

Rabbit
反應種屬：

Drosophila melanogaster (Fruit fly)
免疫原：

Recombinant Drosophila melanogaster (Fruit fly) Piezo protein (1838-1917aa)
免疫原種屬：

Drosophila melanogaster (Fruit fly)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Plays a major role in nociception (response to strong or painful touch). Required for maintaining the mechanosensitivity of tarsal bristle mechanosensors. During their evalulation of potential egg-laying sites, females determine the softest substrate for their eggs first by making a coarse evaluation of substrate hardness using mechanosensitive channels nan and Piezo in the leg tarsal bristles, followed by a much finer assessment using nan, iav and Tmc mechanosensitive channels on the labellum. Acts in the nompC- and nan-expressing neurons of the female leg tarsals, to sense the mild differences in egg-laying substrate stiffness.
基因功能參考文獻：
1. Both vertebrate and invertebrate mechanosensitive PIEZO ion channels are polymodal, being voltage modulated, and can even be directly voltage gated following a preceding mechanical stimulus. PMID: 29545531
2. demonstration of the existence of a specific group of stem cells in the fly midgut that can directly sense mechanical signals through Piezo PMID: 29414942
3. Our findings show that inactivation of these sensory neurons impairs the cellular response against wasp parasitization. We also demonstrate that the nociception genes encoding the mechanosensory receptors Painless and Piezo, both expressed in class IV neurons, are essential for the normal cellular immune response to parasite challenge. PMID: 28342875
4. The mechanosensory channel, Piezo, has been identifieded in larval drosophila dorsal bipolar dendritic sensory neurons, with TRPA1 playing a subsidiary role. PMID: 26186008
5. 11 of 15 aspartate and glutamate residues conserved relative to mouse Piezo1 1,974-2,188 region PMID: 26008989
6. data demonstrate the physiological relevance of the Piezo family in mechanotransduction in vivo, supporting a role of Piezo proteins in mechanosensory nociception PMID: 22343891
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

PIEZO (TC 1.A.75) family
數據庫鏈接：

KEGG: dme:Dmel_CG44122

STRING: 7227.FBpp0289561

UniGene: Dm.18615

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