Phospho-TNS1 (Y1326) Antibody

說明書

中文名稱：

磷酸化-TNS1 (Y1326)兔多克隆抗體
貨號：

CSB-PA000750
規格：

￥1090
圖片：
Western Blot analysis of K562, cells using Phospho-Tensin-1 (Y1326) Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9HBL0
基因名：

TNS1
別名：

matrix-remodelling associated 6 antibody; Matrix-remodelling-associated protein 6 antibody; MGC88584 antibody; MST091 antibody; MST122 antibody; MST127 antibody; MSTP091 antibody; MSTP122 antibody; MSTP127 antibody; MXRA6 antibody; TENS1_HUMAN antibody; Tensin antibody; Tensin-1 antibody; TNS antibody; TNS1 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from Human Tensin-1 around the phosphorylation site of Y1326.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.
基因功能參考文獻：
1. miR-548j functions as a metastasis-promoting miRNA to regulate breast cancer cell invasion and metastasis by targeting Tensin1 and activating Cdc42. PMID: 26949125
2. TNS1 plays an essential role in TGF-beta-induced myofibroblast differentiation. PMID: 28005397
3. TNS1, MET, and TRKC tyrosine-phosphorylated proteins are upregulated during epithelial-mesenchymal transition induced with TGF-beta, and predict the outcome in lung adenocarcinoma patients. PMID: 26216473
4. TNS1 polymorphism associated with COPD risk and lung function decline PMID: 21965014
5. data demonstrate that tensin1 is extensively phosphorylated on Ser/Thr residues in cells and phosphorylation by p38 MAPK regulates the specificity of the tensin1 Src homology 2 domain for binding to different proteins PMID: 20798394
6. The expression of tensin is increased in mesangial cells with stimulating of high concentrations of glucose. PMID: 19664390
7. Data show expression of TNS1, GSTCD, AGER, HTR4 and THSD4 in lung tissue and indicate potential targets for interventions to alleviate respiratory disease. PMID: 20010834
8. Results suggest that PP1alpha bound to tensin1 has effects in reducing migration and invasion that are not mediated through DLC-1, and show the importance of PP1alpha binding to tensin1 for the regulation of cell polarization, migration, and invasion. PMID: 19826001
9. Tensin may play important roles in mesangial ECM production through an adhesion complex with integrin alpha5, FAK, and vinculin. PMID: 14991332
10. Results suggest that the protein-tyrosine phosphatase domain of tensin exhibits isoform-specific association with PP1alpha in a restricted spatial region of adhesions that are formed during cell migration. PMID: 17435217
11. Aged fibroblasts, generated with the Hayflick replicative senescence model, exhibit as siRNA silences fibroblasts, a reduced tensin1 expression and an impaired gel contraction capacity. PMID: 18537817
12. Tensins may represent a novel group of metastasis suppressors in the kidney, the loss of which leads to greater tumor cell motility and consequent metastasis. PMID: 19194507
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亞細胞定位：

Cell surface. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Localized at cell periphery preferentially to fibrillar adhesions than focal adhesions. Translocates from the cell edge to cell center in an ITGB1BP1-dependent manner.
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 11973

OMIM: 600076

KEGG: hsa:7145

STRING: 9606.ENSP00000171887

UniGene: Hs.471381

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