Phospho-TENC1 (Y483) Antibody

說明書

中文名稱：

磷酸化-TENC1 (Y483)兔多克隆抗體
貨號：

CSB-PA008359
規格：

￥1090
圖片：
Western Blot analysis of 3T3 cells using Phospho-Tensin-2 (Y483) Polyclonal Antibody

Western Blot analysis of A549 NIH-3T3 SH-SY5Y K562 HELA cells using Phospho-Tensin-2 (Y483) Polyclonal Antibody
其他：

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靶點詳情

產品詳情

Uniprot No.：

Q63HR2
基因名：

TNS2
別名：

C1 domain containing phosphatase and tensin homolog antibody; C1 domain-containing phosphatase and tensin homolog antibody; C1 TEN antibody; C1-TEN antibody; C1TEN antibody; DKFZp686D13244 antibody; FLJ16320 antibody; KIAA1075 antibody; TENC 1 antibody; TENC1 antibody; TENC1_HUMAN antibody; Tensin 2 antibody; Tensin like C1 domain containing phosphatase antibody; Tensin-2 antibody; Tensin-like C1 domain-containing phosphatase antibody; TNS2 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from Human Tensin-2 around the phosphorylation site of Y483.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:10000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Tyrosine-protein phosphatase which regulates cell motility proliferation and muscle-response to insulin. In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy. Negatively regulates PI3K-AKT pathway activation.
基因功能參考文獻：
1. Patients with low TNS2 expression showed poor relapse-free survival rates for breast and lung cancers. These results strongly suggest a role of tensin2 in suppressing cell transformation and reduction of tumorigenicity. PMID: 27203214
2. p62 expression increased but C1-Ten protein decreased during muscle differentiation, supporting a role for p62 as a physiological regulator of C1-Ten. PMID: 25101860
3. Pulldown studies in human cells using Myc-tagged Tensin2 constructs revealed that DISC1 specifically interacts with the C-terminal PTB domain of Tensin2 in a phosphorylation-independent manner. PMID: 23233134
4. Results identified tensin2 as a Syk-binding protein. PMID: 22019427
5. Here, we report complete chemical shift assignments of the SH2 domain of human tensin2 determined by triple resonance experiments. PMID: 21461930
6. Tensin2 is an important new mediator in TPO/c-Mpl pathway and has a positive affect on cellular growth, at least in part through its effect on the PI3K/Akt signaling. PMID: 21527831
7. Tensin2 SH2 domain was identified to interact with nonphosphorylated ligand (DLC-1) as well as phosphorylated ligand. PMID: 21765928
8. Tensin2, in addition to regulating cytoskeletal dynamics, influences phosphoinositide-Akt signalling through its PTPase domain. PMID: 20678486
9. Data suggest that the interaction between START-GAP1 and tensin2 occurs in a PTB domain-dependent manner. manner.ty=0 PMID: 19895840
10. Differential proteolytic cleavage of Tensin2 can liberate domains with discrete localisations and functions, which has implications for the role of Tensins in cancer cell survival and motility. PMID: 19747564
11. Interaction of Axl receptor tyrosine kinase with C1-TEN. PMID: 12470648
12. C1 domain-containing phosphatase and TENsin homologue (C1-TEN) appears to be a novel intracellular phosphatase that negatively regulates the Akt/Protein kinase B signaling cascade PMID: 15817639
13. variant 3 significantly promoted the cell growth and motility of HCC cells; clonal transfectants of variant 3 were more closely packed and resulted in a higher saturation density than in the control vector transfectants PMID: 17006924
14. Tensins may represent a novel group of metastasis suppressors in the kidney, the loss of which leads to greater tumor cell motility and consequent metastasis. PMID: 19194507
15. DLC1 interaction with tensin2 through this novel focal adhesion binding site contributes to the growth-suppressive activity of DLC1. PMID: 19440389
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亞細胞定位：

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
組織特異性：

Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and small intestine.
數據庫鏈接：

HGNC: 19737

OMIM: 607717

KEGG: hsa:23371

STRING: 9606.ENSP00000319756

UniGene: Hs.343334

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