Phospho-RRN3 (S649) Antibody
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中文名稱：磷酸化-RRN3 (S649)兔多克隆抗體
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貨號：CSB-PA030142
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規格：￥1090
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其他：
產品詳情
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Uniprot No.：
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基因名：RRN3
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別名：AL023001 antibody; DKFZp566E104 antibody; E130302O19Rik antibody; MGC104238 antibody; R75565 antibody; RGD1305001 antibody; RNA polymerase I-specific transcription initiation factor RRN3 antibody; Rrn3 antibody; RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) antibody; RRN3_HUMAN antibody; TIF-IA antibody; TIF1A antibody; TIFIA antibody; Transcription Initiation Factor 1A antibody; Transcription initiation factor IA antibody; Transcription initiation factor TIF IA antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from Human Rrn3 around the phosphorylation site of S649.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction.
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基因功能參考文獻：
- These data support a model in which activated Akt enhances rRNA synthesis both by preventing TIF-IA degradation and phosphorylating CK2alpha, which in turn phosphorylates TIF-IA. PMID: 24297901
- DNA binding by the ribosomal DNA transcription factor rrn3 is essential for ribosomal DNA transcription PMID: 23393135
- reveals the molecular basis of Rrn3-regulated Pol I initiation and cell growth PMID: 21940764
- Data show that nutrient starvation, density arrest and protein synthesis inhibitors inactivate transcription initiation factor-IA and impair its association with RNA polymerase I. PMID: 12393749
- ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth. PMID: 12620228
- Phosphorylation of S44 activates and S199 inactivates TIF-IA. PMID: 15004009
- The definition of the Alu element within the TIF-IA gene as an exon is restricted to certain types of cancers; the element is not exonized in normal human cells. PMID: 18047649
- CK2 phosphorylates the transcription initiation factor TIF-IA at serines 170 and 172 (Ser170/172), and this phosphorylation triggers the release of TIF-IA from Pol I after transcription initiation. PMID: 18559419
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亞細胞定位：Nucleus, nucleolus.
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蛋白家族：RRN3 family
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數據庫鏈接：
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