Phospho-RPS6 (Ser235/236) Antibody

說明書

中文名稱：

磷酸化-RPS6 (Ser235/236)兔多克隆抗體
貨號：

CSB-PA070173
規格：

￥2454
圖片：
Western blot analysis of extracts from Hela cells untreated or treated with UV using S6 Ribosomal Protein(Phospho-Ser235/236) Antibody.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) RPS6 Polyclonal antibody
Uniprot No.：

P62753
基因名：

RPS6
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Peptide sequence around phosphorylation site of serine 235/236 (R-L-S(p)-S(p)-L-R) derived from Human S6 Ribosomal Protein.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Component of the 40S small ribosomal subunit. Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
基因功能參考文獻：
1. JMJD5 catalyzes stereoselective C-3 hydroxylation of arginine residues in sequences from human RCCD1 and ribosomal protein S6. PMID: 29563586
2. single 60-min bout of peristaltic pulse external pneumatic compression transiently upregulates phosphorylated ribosomal protein s6 and the Akt-mTOR signalling cascade. PMID: 26769680
3. MiR-129-5p sensitized Her-2-positive breast cancer to trastuzumab by downregulating rpS6. PMID: 29258115
4. Dual PI3K/mTOR inhibition represents an effective therapeutic strategy in uterine leiomyosarcoma, and p-S6(S240) expression is a potential predictive biomarker for response to treatment. PMID: 28232476
5. this study unveils an unprecedented correlation of mTOR activation with improved clinical outcome in patients with laryngeal carcinomas and uncovers the potential of p-S6 expression as a good prognostic biomarker and an inverse predictor of lymph node and distant metastases. PMID: 27119232
6. the aggregation of rpS6 at the nucleolus correlates to the phasing of cell cycle, beginning to concentrate in the nucleolus at later S phase and disaggregate at M phase. PMID: 26639987
7. Study examined baseline levels of S6 phosphorylated at Ser235/236 (pS6Ser235/236) or Ser240/244 (pS6Ser240/244)and a possible effect of tau pathology. Findings argue against the idea that high levels of pS6Ser235/236 in neurons are a consequence of a higher expression of S6 protein and speak for an increased phosphorylation of S6 in intensely pS6Ser235/236-labeled neurons. PMID: 28119058
8. Data suggest ribosomal protein S6 (rpS6) as tumor marker for renal cell carcinoma. PMID: 26506236
9. Hyperphosphorylation of ribosomal protein S6 predicts unfavorable clinical survival in non-small cell lung cancer PMID: 26490682
10. p-rpS6 is a robust post-treatment indicator of HER2 pathway-targeted therapy resistance PMID: 26329528
11. Resistance to Selumetinib (AZD6244) in colorectal cancer cell lines is mediated by p70S6K and RPS6 activation. PMID: 25379021
12. Tanshinone IIA inhibits HIF-1alpha and VEGF expression in breast cancer cells via mTOR/p70S6K/RPS6/4E-BP1 signaling pathway. PMID: 25659153
13. The expression levels of phospho-mTOR and phospho-S6RP may be potential predictive biomarkers for efficacy of everolimus in patients with metastatic renal cell carcinoma. PMID: 24886512
14. we report that phosphorylation of ribosomal protein S6 is greatly increased in BRCA1 deficient cells resistant to PARP inhibition PMID: 24831086
15. Suggest phosphorylated S6 as an immunohistochemical biomarker of vulvar intraepithelial neoplasia. PMID: 23765247
16. Suggest that p-S6 and the ratio of p-S6/S6 are closely relevant to tumor progression and have prognostic significance in esophageal squamous cell carcinoma. PMID: 22996377
17. S6 phosphorylation at S240/4 is strongly cell cycle-regulated. PMID: 23255058
18. High Ribosomal Protein S6 is associated with renal cell carcinoma metastases. PMID: 21792700
19. a novel mechanism for modulating the RPS6 function by PP1 and ATM which regulates cell growth and survival in response to DNA-damage stim PMID: 22451389
20. Nearly 20-fold more neurons contain pS6-positive granules in Alzheimer's disease hippocampus compared to age-matched controls. PMID: 21968813
21. Downregulation of HELZ reduced translational initiation, resulting in the disassembly of polysomes, in a reduction of cell proliferation and hypophosphorylation of ribosomal protein S6. PMID: 21765940
22. Here, the authors show that ribosomal protein S6 (RPS6) interacts with LANA. PMID: 21734034
23. The mTOR/S6 signal pathway is activated in refractory/relapsed aplastic anemia, and can be suppressed by rapamycin or CTLA-4Ig. PMID: 19954658
24. RPS6 associates with multiple mRNAs containing a 5' terminal oligopyrimidine tract. These findings expand our understanding of the mechanism(s) involved in ribosomal biogenesis and deregulated protein synthesis in diffuse large B-cell lymphoma (DLBCL). PMID: 21102526
25. S240/244-phosphorylated S6 is predominantly nuclear but detectable in the cytoplasm, whereas S235/236-phosphorylated S6 is exclusively localized to the nucleus. PMID: 20625781
26. Regulation of ribosomal protein S6 phosphorylation by casein kinase 1 and protein phosphatase 1. PMID: 21233202
27. Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma. PMID: 21147110
28. Data show that the mTOR effectors, 4EBP1, p70S6K and rpS6, are highly activated in cultured and primary FLT3-mutated acute myeloid leukemia (AML) cells. PMID: 21067588
29. when exercise is performed in a fasted state, the increase in phosphorylation of signalling molecules such as p70(S6k) and the S6 ribosomal protein in human muscle depends on the exercise volume PMID: 20617335
30. Genetic alterations of TP53 and RPS6 were different in different areas of the same oral squamous cell carcinoma tumor. PMID: 17565818
31. Rheb is a mediator of RPS6. PMID: 12820960
32. IFNgamma-activated p70 S6 kinase phosphorylates the 40S S6 ribosomal protein on serines 235/236, to regulate IFNgamma-dependent mRNA translation. PMID: 15051500
33. Cortical tuber giant cells in a case of epileptogenic tuberous sclerosis showed predominantly nuclear hamartin, cytosolic tuberin, and hyperphosphorylation of S6. PMID: 15477556
34. the phosphorylation of Tyr(1077) on LepRb during receptor activation, substantiate the hypothalamic regulation of STAT5 and S6 by leptin, and define the alternate LepRb signaling pathways PMID: 17726024
35. Structure, localization and molecular assembly in vitro and in vivo of a human rpS6, were examined using antibodies (Abs) prepared by immunizing rabbits with synthetic peptides. PMID: 18039684
36. The level of phosphorylated S6 ribosomal protein expression was predictive of early tumor response to the mammalian target of rapamycin (mTOR)inhibitor, suggesting that this is a promising new predictive sarcoma marker for targeted mTOR inhibitor therapy PMID: 18157089
37. The results demonstrate that multiple muscarinic receptor subtypes regulate mTOR, and that both MAPK-dependent and -independent mechanisms may mediate the response in a cell context-specific manner. PMID: 18348264
38. rpS6, especially in its unphosphorylated form, is a selective mediator of TRAIL-induced apoptosis PMID: 18362888
39. Resistance exercise decreases eIF2Bepsilon phosphorylation and potentiates the feeding-induced stimulation of p70S6K1 and rpS6 in young men. PMID: 18565837
40. Basophilic inclusions from patients with adult-onset atypical motor neuron disease were distinctly labeled with the antibodies against poly(A)-binding protein 1, T cell intracellular antigen 1, and ribosomal protein S6. PMID: 18642007
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蛋白家族：

Eukaryotic ribosomal protein eS6 family
數據庫鏈接：

HGNC: 10429

OMIM: 180460

KEGG: hsa:6194

STRING: 9606.ENSP00000369757

UniGene: Hs.408073

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