Phospho-RGS16 (Y168) Antibody
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中文名稱：磷酸化-RGS16 (Y168)兔多克隆抗體
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貨號：CSB-PA040215
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規格：￥1090
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其他：
產品詳情
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Uniprot No.：
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基因名：RGS16
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別名：A28 RGS14 antibody; A28 RGS14P antibody; A28-RGS14P antibody; HGNC:9997 antibody; hRGS-r antibody; OTTHUMP00000033147 antibody; Regulator of G protein signaling 16 antibody; Regulator of G protein signalling 16 antibody; Regulator of G-protein signaling 16 antibody; Retinal-specific RGS antibody; Retinally abundant regulator of G protein signaling antibody; Retinally abundant regulator of G-protein signaling antibody; RGS 16 antibody; RGS R antibody; RGS-R antibody; Rgs14 antibody; RGS16 antibody; RGS16_HUMAN antibody; RGSR antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat,Monkey
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免疫原：Synthesized peptide derived from Human RGS16 around the phosphorylation site of Y168.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals.
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基因功能參考文獻：
- Data suggest that RGS16 functions as a GAP (GTPase accelerating protein) in the SCN (suprachiasmatic nucleus) and is required for circadian timing. [REVIEW] PMID: 28502923
- The data establish miR-181a as an oncomiR that promotes chondrosarcoma progression through a new mechanism involving enhancement of CXCR4 signaling by inhibition of RGS16. PMID: 26013170
- suggest that deltaEF1 family proteins promote cell motility of breast cancer cells directly or indirectly through repressing expression of RGS16 PMID: 26823172
- these results indicate that RGS16 restricts the activation-induced pro-inflammatory profile in myeloid cells. PMID: 25366993
- Data indicate that multiplex ligation-dependent probe amplification (MLPA) probes (Fig. 2) corresponding to the RGSL2, RGSL1 and RGS16 genes showed 64.5 % tumour samples with copy number gains and 5 % tumour samples with copy number losses. PMID: 23248035
- cotreatment with RGS16 siRNA reversed the downregulation of nuclear factor-kappaB expression induced by combined inhibition of LSD1 and HDACs, suggesting a crucial role of RGS16 in controlling key pathways of cell death in response to combination therapy. PMID: 23354309
- Missense mutations in RGS16 gene is associated with breast cancer. PMID: 21135262
- RGS16 and FosB are underexpressed in pancreatic cancer with lymph node metastasis and associated with reduced survival PMID: 20571966
- Increased RGS16 levels are associated with colorectal cancer. PMID: 19760045
- Src mediates RGS16 tyrosine phosphorylation, which may promote RGS16 stability. PMID: 12588871
- results suggest that the amino-terminal palmitoylation of regulator of G-protein signaling 16 protein(RGS16) promotes its lipid raft targeting that allows palmitoylation of a poorly accessible cysteine residue PMID: 12642593
- RGS16 inhibits G alpha 13-mediated, RhoA-dependent reversal of stellation and Serum Response Element activation, thus regulating G alpha 13-mediated signal transduction independently of the RGS box. PMID: 14634662
- RGS16 is a negative regulator of SDF-1-CXCR4 signaling in megakaryocytes PMID: 15998835
- G alpha(i2) is specifically localized in human Fallopian tube epithelial cells, particularly in cilia, & is likely to have cilia-specific role in reproduction. PMID: 17347170
- B4GALT3, DAP3, RGS16, TMEM183A and UCK2--were significantly overexpressed in dup(1q)-positive ALLs compared with high hyperdiploid ALLs without dup(1q). PMID: 17613536
- Regulator of G Signaling 16 has a role in the distinct endoplasmic reticulum stress state associated with aggregated mutant alpha1-antitrypsin Z in the classical form of alpha1-antitrypsin deficiency PMID: 17635928
- The promoter region of RGS16 was found to be methylated in 10% human breast carcinomas PMID: 18521847
- the loss of RGS16 in some breast tumors enhances PI3K signaling elicited by growth factors and thereby promotes proliferation and TKI evasion downstream of HER activation PMID: 19509421
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亞細胞定位：Membrane; Lipid-anchor.
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組織特異性：Abundantly expressed in retina with lower levels of expression in most other tissues.
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數據庫鏈接：
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