Phospho-NUDC (S326) Antibody
-
中文名稱：磷酸化-NUDC (S326)兔多克隆抗體
-
貨號：CSB-PA006692
-
規格：￥1090
-
圖片：
-
Western Blot analysis of JK cells using Phospho-NUDC (S326) Polyclonal Antibody
-
-
其他：
產品詳情
-
Uniprot No.：
-
基因名：NUDC
-
別名：HNUDC antibody; MNUDC antibody; MNUDC protein antibody; NPD011 antibody; Nuclear distribution C homolog antibody; Nuclear distribution gene C (A.nidulans) homolog antibody; Nuclear distribution gene C homolog antibody; Nuclear distribution gene C homolog (A. nidulans) antibody; Nuclear distribution protein C homolog antibody; Nuclear migration protein nudC antibody; nudC antibody; NudC nuclear distribution protein antibody; NUDC_HUMAN antibody; OTTHUMP00000004405 antibody; SIG 92 antibody; SIG92 antibody
-
宿主：Rabbit
-
反應種屬：Human,Mouse,Rat
-
免疫原：Synthesized peptide derived from Human NUDC around the phosphorylation site of S326.
-
免疫原種屬：Homo sapiens (Human)
-
標記方式：Non-conjugated
-
抗體亞型：IgG
-
純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-
濃度：It differs from different batches. Please contact us to confirm it.
-
保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
-
產品提供形式：Liquid
-
應用范圍：WB, IHC, ELISA
-
推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:5000 -
Protocols：
-
儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
-
功能：Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.
-
基因功能參考文獻：
- High expression of NUDC is associated with prostate cancer. PMID: 27959429
- the upregulation of miR-194 affects the hNUDC expression, leading to a downregulated expression of Mpl/ERK pathway proteins, and suppresses the mitosis and proliferation of NSCLC cells. PMID: 27035759
- NudC is co-localized with Aurora B at the midbody and co-immunoprecipitated with Aurora B in mitosis. results suggest that that dynamic phosphorylation of NudC by Aurora B regulates cytokinesis. PMID: 27074040
- NudC acetylation/deacetylation regulates mitotic progression and NudC deacetylation, likely through HDAC3, is critical for spindle function and chromosome congression. PMID: 24069238
- Human nuclear distribution C is found to be closely associated with cell malignant hyperplasia in nasopharyngeal carcinoma. PMID: 21473139
- NudC may be involved in the regulation of LIS1 stability by its chaperone function. PMID: 20675372
- separate binding sites on the Mpl receptor for TPO and hNUDC identified PMID: 20529857
- Mpl plays an important and specific role in mediating hNUDC-induced megakaryocyte proliferation and differentiation. PMID: 19560457
- functions in mitosis and cytokinesis, in part by regulating microtubule organization at the midzone and midbody PMID: 12679384
- PLK1 phosphorylation of NudC plays an essential role in cytokinesis. PMID: 12852857
- Overexpression of NUDC inhibits prostatic neoplasm growth. PMID: 14676831
- In this study, we report the binding of hNUDC to the extracellular domain of the thrombopoietin receptor (Mpl) as detected by the yeast two-hybrid system, GST pull-down, and co-immunoprecipitation. PMID: 16088917
- NudC functions as both a substrate and a spatial regulator of Plk1 at the kinetochore to promote chromosome congression. PMID: 16860740
- hNUDC induced significant changes in cellular morphology in NIH 3T3 cells stably transfected with pMpl-EGFP. Interestingly, these morphological changes were characteristic of cells undergoing megakaryocyte differentiation. PMID: 17658515
- hNUDC induced a sustained activation of the extracellular signal-regulated protein kinases-1 and -2 (ERK1/2) as well as p38 mitogen-activated kinase (p38 MAPK) pathways PMID: 18288130
顯示更多
收起更多
-
亞細胞定位：Cytoplasm, cytoskeleton. Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody.
-
蛋白家族：NudC family
-
組織特異性：Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart.
-
數據庫鏈接：
Most popular with customers
-
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-
-
