Phospho-MEF2D (S444) Antibody

說明書

中文名稱：

磷酸化-MEF2D (S444)兔多克隆抗體
貨號：

CSB-PA010173
規格：

￥1090
圖片：
Western blot analysis of K562 AD293 using Phospho-MEF-2D (S444) antibody.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q14814
基因名：

MEF2D
別名：

DKFZp686I1536 antibody; MADS box transcription factor 2 polypeptide D antibody; Mef2d antibody; MEF2D_HUMAN antibody; Myocyte enhancer factor 2D antibody; Myocyte specific enhancer factor 2, polypeptide D antibody; Myocyte specific enhancer factor 2D antibody; Myocyte-specific enhancer factor 2D antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from Human MEF-2D around the phosphorylation site of S444.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:10000

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis.
基因功能參考文獻：
1. Our study suggests that the MEF2D, PRDM16 and ASTN2 genes from GWAS are associated with migraine susceptibility, especially migraine without aura , among Chinese patients. It appears that there is no association with serotonin receptor related genes. PMID: 28058730
2. In summary, we found that miR-1244 affected cisplatin-treated non-small cell lung cancer via MEF2D expression. PMID: 28498474
3. MEF2d mRNA level is up-regulated in both sporadic and SOD1 + ALS patients. PMID: 26921792
4. MEF2D might be a potential biomarker during chronic inflammation-lung cancer transition, predicting the risk of lung cancer among patients with chronic respiratory diseases. PMID: 28340574
5. HIF-1alpha transactivates MEF2D expression by binding to the MEF2D gene promoter to induce angiogenesis in colorectal tumors. PMID: 28478181
6. MEF2D directly regulated transcription of the epithelial-mesenchymal transition driver gene ZEB1 and facilitated histone acetylation at the ZEB1 promoter in colorectal cancer cells PMID: 27364559
7. MEF2D-BCL9-positive patients had B-cell precursor immunophenotype and were characterized as being older in age, being resistant to chemotherapy, having very early relapse, and having leukemic blasts that mimic morphologically mature B-cell leukemia with markedly high expression of HDAC9. PMID: 27507882
8. These results suggest that PPARgamma may exert its antiproliferative effects by negatively regulating the MEF2D in CM cells, which through upregulation of miR-122, and PPARgamma/miR-122/MEF2D signaling pathway may be a novel target for treatment of CM. PMID: 27109478
9. MEF2D overexpression participated in the growth of lung cancers and its aberrant expression may result from the reduction of tumor suppressor miR-218. PMID: 26409449
10. MEF2D is a direct target of miR-19. PMID: 26762410
11. We found that in malignant glioma, there is an aberrantly high expression of MEF2D, which leads to poor prognosis of malignant glioma. The downregulation of MEF2D suppresses the proliferation of malignant glioma cell lines by inducing delay of S and G2/M phases of cell cycle and promoting apoptosis. PMID: 26234765
12. MEF2D regulates IGF-1-induced proliferation and apoptosis in CM development, indicating IGF-1-MEF2D pathway may be a useful target for treatment. PMID: 26563368
13. Pokemon was found to enhance the migration and invasion of hepatocellular carcinoma by increasing MEF2D expression PMID: 26797719
14. miR-1244 and MEF2D form an autoregulatory loop contributing to the progression of lung carcinoma. PMID: 26355845
15. MEF2D was also found to increase the transcription of Pokemon by binding myocyte enhancer factor 2 (MEF2) sites within its promoter region, that can promote Hepatocellular carcinoma invasion PMID: 26164003
16. Cell cycle progression was also inhibited by MEF2D suppression. PMID: 25812649
17. OA induced cell cycle arrest in lung cancer cells through miR-122/Cyclin G1/MEF2D pathway. This finding may contribute to the understanding of the molecular mechanism of OA's anti-tumor activity PMID: 25472877
18. MEF2D suppression was shown to decrease the proliferation of osteosarcoma cells. PMID: 25814384
19. Oxidation of survival factor MEF2D inhibits its function, underlies oxidative stress-induced neurotoxicity, and may be a part of the Parkinson disease pathogenic process. PMID: 24219011
20. The oncogenic properties of rhabdomyosarcoma cells can be partially attributed to the loss of MEF2D expression. PMID: 24279793
21. MEF2D-silencing abolished hepatocellular carcinoma tumorigenicity. PMID: 24390737
22. The expression of MEF2D was higher in the higher clinical stage of nasopharyngeal carcinoma, but there was no correlation with survival rate. PMID: 22256741
23. direct regulation of complex I by mitochondrial MEF2D underlies its neuroprotective effects, and dysregulation of this pathway may contribute to Parkinson disease PMID: 21393861
24. data implicate MEF2D in human cancer and suggest that MEF2D/DAZAP1 and/or DAZAP1/MEF2D contribute to leukemogenesis by altering signaling pathways normally regulated by wild-type MEF2D and DAZAP1 PMID: 15744350
25. histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications regulate MEF2 PMID: 16166628
26. These results reveal an unexpected role for HDAC3 and suggest a novel pathway through which MEF2 activity is controlled in vivo. PMID: 17158926
27. MEF2D levels were increased in the brains patients with Parkinson's disease PMID: 19119233
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亞細胞定位：

Nucleus. Note=Translocated by HDAC4 to nuclear dots.
蛋白家族：

MEF2 family
數據庫鏈接：

HGNC: 6997

OMIM: 600663

KEGG: hsa:4209

STRING: 9606.ENSP00000271555

UniGene: Hs.314327

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