Phospho-HBP1 (Ser402) Antibody

中文名稱：

磷酸化-HBP1 (Ser402)兔多克隆抗體
貨號(hào)：

CSB-PA204919
規(guī)格：

￥2454
圖片：
Western blot analysis of extracts from A549 cells, treated with PMA (125ng/ml, 30mins), using HBP1 (Phospho-Ser402) antibody. The lane on the right is treated with the synthesized peptide.
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
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靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) HBP1 Polyclonal antibody
Uniprot No.：

O60381
基因名：

HBP1
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse
免疫原：

Peptide sequence around phosphorylation site of serine 402 (C-G-S(p)-P-G) derived from Human HBP1.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
濃度：

It differs from different batches. Please contact us to confirm it.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.
基因功能參考文獻(xiàn)：
1. Study shows that RORbeta is a transcriptional enhancer of inhibitor HBP1 of the Wnt pathway. NRIP2 prevents RORbeta to bind with downstream HBP1 promoter regions and reduces the transcription of HBP1. These results provide evidence that interactions between NRIP2, RORbeta, and HBP1 mediate a new mechanism for CCIC self-renewal via the Wnt activity. PMID: 28137278
2. Low HBP1 expression is associated with invasive oral cancer. PMID: 28099936
3. induced premature senescence and apoptosis. Furthermore, the Pim-1-HBP1 positive feedback loop exerts its effect by regulating the senescence markers DNMT1 and p16 and the apoptosis marker Bax. The Pim-1-HBP1 axis thus constitutes a novel checkpoint pathway critical for the inhibition of tumorigenesis. PMID: 28348080
4. miR155 may contribute to the progression and growth of Colorectal carcinomaby enhancing the Wnt/betacatenin pathway in an HBP1associated mechanism. PMID: 26780942
5. Data suggest HMG-box transcription factor (HBP1) as a target in prostate cancer radiotherapy. PMID: 26942107
6. Data show that HMG-box transcription factor 1 protein HBP1-mediated elevation of CDK inhibitor p21 through the Mdm2/p53 and TCF4/EZH2 pathways contributes to both cellular senescence and tumor inhibition. PMID: 27129219
7. All trans-retinoic acid can reverse the suppressive effect of MED28 on HBP1 and E-cadherin and inactivate the Wnt/beta-catenin pathway in colorectal cancer, suggesting a protective effect of ATRA against colorectal cancer. PMID: 26660958
8. HBP1-mediated Wnt signaling is involved with the role of miR-155 in osteosarcoma progression. PMID: 25666090
9. Hbp1 plays a crucial role in regulating the timing of cortical neurogenesis by elongating the cell cycle and that it is essential for normal cortical development. PMID: 26041766
10. HBP1 is a suppressor of cancer progression and a regulator of CTNNB1 gene transcription. PMID: 24895061
11. miR-96/HBP1/Wnt/beta-catenin regulatory circuitry promotes the proliferation of glioma cell PMID: 24931370
12. HBP1 is a novel target of the PI3K/FOXO pathway and controls cell proliferation in response to growth factors. PMID: 24762137
13. acetylation of TCF4E is a novel regulatory mechanism that diversifies the transcriptional output of Wnt/beta-catenin signaling PMID: 23613959
14. HBP1 represses the DNMT1 gene through binding a high-affinity site in the DNMT1 promoter. PMID: 23249948
15. Cis-acting regulatory polymorphisms acting on HBP1 contribute to the osteoarthritis association signal at chromosome 7q22. PMID: 22586168
16. miR-17-5p plays an important role in breast cancer cell invasion and migration by suppressing HBP1 and subsequent activation of Wnt/beta-catenin PMID: 20505989
17. HBP1 targets P16(INK4A), upregulating its expression and consequently is involved in Ras-induced premature senescence. PMID: 20581871
18. HBP1 directly inhibits MIF gene transcription, which is overexpressed in prostatic cancer. PMID: 20383199
19. HBP1 binds c-Myc in cells, and expression of HBP1 inhibits c-Myc transactivational activity at least partly by preventing c-Myc binding to target gene promoters. PMID: 20008325
20. NMR study of the AXH domain PMID: 14872137
21. Results indicate that HBP1 may contribute to the regulation of NADPH oxidase-dependent superoxide production through transcriptional repression of the p47phox gene. PMID: 15024088
22. HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations PMID: 15235594
23. in myeloid cells HBP1 may serve as a tumor suppressor and a general differentiation inducer and may synergize with chemical differentiating agents to enhance lineage-specific differentiation PMID: 16179914
24. Transgenic mice overexpressing HBP1 exhibit altered thymus cellularity and decreased thymocyte development. PMID: 16210625
25. EGCG blocks Wnt signaling by inducing the HBP1 transcriptional repressor and inhibits aspects of invasive breast cancer PMID: 16495219
26. these studies highlight p38 MAPK, HBP1, and RB as important components for a premature-senescence pathway with possible clinical relevance to breast cancer. PMID: 16966377
27. HBP1 transcriptional repressor alterations are associated with invasive breast cancer PMID: 17616670
28. HBP1 regulates the cell cycle in liver regeneration and provides evidence for a role in tissue maintenance. PMID: 11486012
29. HBP1 is a suppressor of Wnt signalling and lies in a region that is mutated in cancer. PMID: 11500377
30. HBP1 was isolated as a cell cycle inhibitor and HMG-box transcriptional repressor. PMID: 9030690
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亞細(xì)胞定位：

Nucleus.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 23200

KEGG: hsa:26959

STRING: 9606.ENSP00000222574

UniGene: Hs.162032

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