Phospho-HAND1 (S98) Antibody
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中文名稱：磷酸化-HAND1 (S98)兔多克隆抗體
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貨號：CSB-PA080002
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規格：￥1090
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：autonomic nervous system and neural crest derivatives-expressed protein 1 antibody; Basic helix loop helix transcription factor HAND1 antibody; bHLHa27 antibody; Class A basic helix-loop-helix protein 27 antibody; eHAND antibody; Extraembryonic tissues antibody; Extraembryonic tissues heart autonomic nervous system and neural crest derivatives expressed protein 1 antibody; HAND 1 antibody; HAND1 antibody; HAND1_HUMAN antibody; Heart and neural crest derivatives expressed 1 antibody; Heart and neural crest derivatives expressed protein 1 antibody; heart antibody; Heart- and neural crest derivatives-expressed protein 1 antibody; Hxt antibody; Thing 1 antibody; Thing1 antibody; Thing1 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from Human HAND1 around the phosphorylation site of S98.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution IHC 1:100-1:300 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box). Acts as a transcriptional repressor of SOX15. In the adult, could be required for ongoing expression of cardiac-specific genes.
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基因功能參考文獻：
- Strikingly, human pluripotent stem cell antibody array showed that Hand1 overexpression resulted in substantial decrease in pluripotency markers (Nanog, Oct3/4, Otx2, Flk1) suggesting that Hand1 expression may be essential to attenuate the EMT and our findings underscore a novel role for Hand1 in medulloblastoma metastasis. PMID: 27297109
- association of HAND1 loss-of-function mutation with increased susceptibility to Tetralogy of Fallot PMID: 27942761
- These findings expand the phenotypic spectrum linked to HAND1 mutations, suggesting potential implications for the development of novelo prophylactic and therapeutic strategies for DORV. PMID: 28112363
- HAND1 loss-of-function mutation is associated with familial dilated cardiomyopathy. PMID: 26581070
- Combined expression of NKX2-5, HAND1, and NOTCH1 coordinately contribute to cardiac malformations in Hhypoplastic left heart syndrome. PMID: 25050861
- These data show that miR-363 negatively regulates the expression of HAND1 PMID: 24906886
- Nuclear translocation of Hand-1 acts as a molecular switch to regulate vascular radiosensitivity in medulloblastoma tumors. PMID: 24623737
- DNA methylation status of NKX2-5, GATA4 and HAND1 in patients with tetralogy of fallot PMID: 24182332
- Increased methylation levels of HAND1 is associated with highly active Helicobacter pylori-related gastritis. PMID: 23292007
- This is the first report of mutations in the HAND1 gene in Chinese patients with VSD and provides new insight into the etiology of VSD PMID: 22032825
- Hand1 is dispensable for normal tyrosine hydroxylase and dopamine beta-hydroxylase expression in sympathetic neurons, even when Hand2 gene dosage is concurrently reduced by half. PMID: 22323723
- Somatic mutations in NKX2-5, GATA4, and HAND1 are not a common cause of tetralogy of Fallot or hypoplastic left heart. PMID: 22043484
- Mutations or sequence variations in HAND1 or NKX2-5 genes may play role in etiology or pathogenesis of atrial isomerism. PMID: 21561848
- Our study shows no evidence of somatic NKX2-5, GATA4 and HAND1 mutations playing a role in the pathogenesis of Tetralogy of Fallot . Findings suggest that the GATA4 and HAND1 germline mutations are associated with non-syndromic congenital heart disease. PMID: 21519287
- Hand1 lineage marks the proepicardial organ and epicardium necessary for epicardial and coronary vessel development, defining the epicardial precursors that are subsequently dependent on Hand2 function. PMID: 21350214
- effects of gene mutations on ventricular development PMID: 12858532
- MEF2/HAND1 interaction results in synergistic activation of MEF2-dependent promoters, and MEF2 binding sites are sufficient to mediate this synergy PMID: 16043483
- In 24 of 31 hypoplastic ventricles, a frameshift mutation was detected in the bHLH domain, which is necessary for DNA binding and combinatorial interactions; thus in hypoplastic human hearts HAND1 function is impaired. PMID: 18276607
- HMGA1 proteins bind directly to Hand1 promoter both in vitro and in vivo and inhibit Hand1 promoter activity PMID: 19060921
- HAND1 sequence mutations are frequent in human hearts with septation defects. PMID: 19586923
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亞細胞定位：Nucleus, nucleoplasm. Nucleus, nucleolus.
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組織特異性：Heart.
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數據庫鏈接：
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