Phospho-GRIA4 (S862) Antibody

說明書

中文名稱：

磷酸化-GRIA4 (S862)兔多克隆抗體
貨號(hào)：

CSB-PA008958
規(guī)格：

￥1090
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

Uniprot No.：

P48058
基因名：

GRIA4
別名：

AMPA 4 antibody; AMPA selective glutamate receptor 4 antibody; AMPA-selective glutamate receptor 4 antibody; AMPA4 antibody; GluA 4 antibody; GluA4 antibody; GluR 4 antibody; GluR D antibody; GluR-4 antibody; GluR-D antibody; GluR4 antibody; GLUR4C antibody; GLURD antibody; Glutamate receptor 4 antibody; Glutamate receptor ionotrophic AMPA 4 antibody; Glutamate receptor ionotropic antibody; GRIA 4 antibody; Gria4 antibody; GRIA4_HUMAN antibody; Ionotropic Glutamate receptor 4 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from Human GluR4 around the phosphorylation site of S862.
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

WB, IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:5000

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
基因功能參考文獻(xiàn)：
1. The authors suggest that pathogenic de novo variants in GRIA4 lead to intellectual disability with or without seizures, gait abnormalities, problems of social behavior, and other variable features. PMID: 29220673
2. Study shows that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluA4 is expressed on oligodendrocytes, myelin and on axons in humans. PMID: 27443784
3. This study demonstrated that the GRIA4 protein was altered in auditory cortex patient with schizophreia. PMID: 25433904
4. Interaction with the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluR4. PMID: 24962026
5. Did not observed any significant association between GRIA4 polymorphisms and clinical improvement in patients with Major depressive disorder. PMID: 22057216
6. SNPs within GRIA4 may not be associated with the development and treatment outcomes in BD PMID: 22122651
7. No significant association GRIA4 polymorphisms was found with the diagnosis of schizophrenia. PMID: 22094384
8. characterization of homomeric alpha-amino-3-hydroxy-5-methylisoxazolepropionate (AMPA)-selective GluR-D glutamate receptors carrying N-terminal deletions PMID: 12393905
9. Results suggest that at least one susceptibility locus for schizophrenia is located within or very close to the GRIA4 region in Japanese. PMID: 12497607
10. alternative splicing isoform of GluR4, human GluR4c has a 113-bp insert containing a stop codon, resulting in a short C terminus. PMID: 15306133
11. The minimal kinetic mechanism for channel opening is consistent with binding of two glutamate molecules per receptor complex. PMID: 15823042
12. GluR4 may regulate its synaptic targeting through phosphorylation-dependent interactions with alpha-Actinin-1 and IQGAP1 PMID: 16190873
13. The present findings show that the interaction between PKCgamma and GluR4 is specifically required to assure PKC-driven phosphorylation and surface membrane expression of GluR4. PMID: 17233759
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亞細(xì)胞定位：

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite.
蛋白家族：

Glutamate-gated ion channel (TC 1.A.10.1) family, GRIA4 subfamily
數(shù)據(jù)庫(kù)鏈接：

HGNC: 4574

OMIM: 138246

KEGG: hsa:2893

STRING: 9606.ENSP00000282499

UniGene: Hs.503743

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