Phospho-AURKC (Thr236/202) Antibody

說明書

中文名稱：

磷酸化-AURKC (Thr236/202)兔多克隆抗體
貨號：

CSB-PA238732
規格：

￥2454
圖片：
Immunohistochemistry analysis of paraffin-embedded human brain tissue using AurB/C (Phospho-Thr236/202) antibody. The picture on the right is treated with the synthesized peptide.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) AURKC Polyclonal antibody
Uniprot No.：

Q9UQB9
基因名：

AURKC
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Peptide sequence around phosphorylation site of threonine 236/202 (C-G-T(p)-L-D) derived from Human AurB/C.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:50-1:100

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
基因功能參考文獻：
1. Teratozoospermia is not correlated with c.144delC mutation in the AURKC gene in the men of the Sichuan area. Therefore, large-scale genotyping of the AURKC gene may not be necessary clinically among Chinese patients with idiopathic teratozoospermia. PMID: 29738175
2. The epigenetic targets AURKB, AURKC and DNMT3B, and the global DNA methylation profile are regulated during HIV-1 replication in CD4+ T cells, and this regulation can be influenced by the activation state of the cell at the time of infection. PMID: 30077875
3. Two novel DMRs, located in RPS6KA4/MIR1237 and the AURKC promoter, were found to be hypermethylated in WT PMID: 28930610
4. Identification and characterization of AURKB and AURKC variants associated with maternal aneuploidy has been reported. PMID: 28369513
5. Aurora-C interactions with members of the Chromosome Passenger Complex (CPC), Survivin and Inner Centromere Protein (INCENP) in reference to known Aurora-B interactions to understand the functional significance of Aurora-C overexpression in human cancer cells, is reported. PMID: 27332895
6. Patients presenting with a monomorphic teratozoospermia such as globozoospermia or macrospermia with more than 85% of the spermatozoa presenting this specific abnormality have been analyzed permitting to identify several key genes for spermatogenesis such as AURKC and DPY19L2. PMID: 27779748
7. Homozygous c.144delC mutation in AURKC gene in infertile men with macrozoospermia in the Tunisian population PMID: 26341096
8. AURKC mutations are more frequent than Klinefelter syndrome and constitute the leading genetic cause of infertility in North African men. PMID: 25219909
9. Low AURKC expression is associated with cancer. PMID: 25990457
10. Overexpression of AURKC is associated with breast tumors. PMID: 25994570
11. may play an important role in the development of colorectal cancer PMID: 26118178
12. Aberrantly expressed Aurora-C in somatic cancer cells may impair spindle checkpoint assembly by displacing the centromeric localization of chromosomal passenger complexes. PMID: 24603334
13. Our data indicate that the AURKC c.144delC mutation has a relatively high carrier frequency in the Moroccan population. PMID: 24484996
14. expression of AURKC, OIP5, PIWIL2 and TAF7L differed between patients with Acute myeloid leukemia, myelodysplastic syndrome and healthy controls in a gender-dependent manner PMID: 23292864
15. Here we provide evidence for the first time of Aurora-C overexpression and gene amplification. PMID: 23581231
16. Investigators identified a new non-sense mutation in aurora kinase C, p.Y248*, in 10 unrelated individuals of European and North African origin; this mutation is associated with macrozoospermia and male infertility. PMID: 22888167
17. Molecular analysis of the AURKC gene was carried out in two brothers presenting with a typical large-headed spermatozoa phenotype. Both affected brothers were heterozygous for the c.144delC mutation in the AURKC gene. PMID: 21733974
18. Aurora C mRNA is up-regulated with Aurora B after activation of the embryonic genome and both proteins were detected in early Day 4 embryos. PMID: 21493633
19. we show that elevated AURKC increases the proliferation, transformation and migration of cancer cells PMID: 21710690
20. Overexpressed Aurora-C (AURKC) is an oncogene. Overexpression of Aurora-C induces abnormal cell division resulting in centrosome amplification and multinucleation. Cells overexpressing active Aurora-C induced tumour formation in nude mice. PMID: 22046298
21. We confirm in this study the research interest of the recurrent mutation c.144delC in the gene AURKC in male infertility with high rates of large-headed spermatozoa PMID: 21353399
22. the study demonstrated that TACC1 localizes at the midbody during cytokinesis and interacts with and is a substrate of Aurora-C, which warrant further investigation in order to elucidate the functional significance of this interaction. PMID: 21531210
23. Aurora-C mRNA was reduced to 0.20 +/- 0.32 fold (P < 0.01) in 13 seminomas and up-regulated in one case PMID: 20629650
24. association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C PMID: 15316025
25. Aurora-C interacts with the inner centromere protein (INCENP) at the carboxyl terminal end spanning the conserved IN box domain. PMID: 15499654
26. Therefore, we speculated that Aurora C-SV might also contribute to the regulation of chromosome segregation and cytokinesis. PMID: 15670791
27. Aurora-C is a chromosomal passenger protein that disrupts the association of INCENP with Aurora-B and may serve as a key regulator in cell division PMID: 15917996
28. Aurora-c is directly associated with surwvivin and is required for cytokinesis. PMID: 15938719
29. A role of Aurora-C in the development and progression of cancer especially in the presence of mutated p53. PMID: 16258285
30. Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility. PMID: 17435757
31. Results demonstrate that human Auroras a regulator of cell morphology and cell growth, and that the non-conserved T191 in the activation loop of Auroras of major importance for its regulation. PMID: 17637569
32. Aurora C phosphorylates TRF2 PMID: 18309533
33. A functional AURKC protein is necessary for male meiotic cytokinesis while its absence does not impair oogenesis. PMID: 19147683
34. Aurora-C can perform the same essential functions as Aurora-B in mitosis: regulation of kinetochore-microtubule attachments, the spindle assembly checkpoint, and cytokinesis PMID: 19713763
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相關疾病：

Spermatogenic failure 5 (SPGF5)
亞細胞定位：

Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle.
蛋白家族：

Protein kinase superfamily, Ser/Thr protein kinase family, Aurora subfamily
組織特異性：

Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase.
數據庫鏈接：

HGNC: 11391

OMIM: 243060

KEGG: hsa:6795

STRING: 9606.ENSP00000302898

UniGene: Hs.98338

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