Pdgfd Antibody, HRP conjugated

說明書

中文名稱：

Pdgfd兔多克隆抗體, HRP偶聯(lián)
貨號：

CSB-PA852889LB01MO
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Mus musculus (Mouse) Pdgfd Polyclonal antibody
Uniprot No.：

Q925I7
基因名：

Pdgfd
別名：

Pdgfd antibody; Scdgfb antibody; Platelet-derived growth factor D antibody; PDGF-D antibody; Spinal cord-derived growth factor B antibody; SCDGF-B) [Cleaved into: Platelet-derived growth factor D antibody; latent form antibody; PDGFD latent form); Platelet-derived growth factor D antibody; receptor-binding form antibody; PDGFD receptor-binding form)] antibody
宿主：

Rabbit
反應種屬：

Mouse
免疫原：

Recombinant Mouse Platelet-derived growth factor D protein (24-370AA)
免疫原種屬：

Mus musculus (Mouse)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Has oncogenic potential and can induce tumor formation. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix.
基因功能參考文獻：
1. Data (including data from studies using transgenic/mutant mice and cells from such mice) suggest that Pdgfd promotes cell proliferation, cell migration, and expression of inflammatory factors in adventitial fibroblasts; in obese mice, inhibition of Pdgfd significantly reduces aortic aneurysm formation (induced by infusion of angiotensin II). PMID: 29794241
2. upregulated in kidney fibrosis, may mediate renal scarring, and is dispensable for normal kidney development and physiological functions PMID: 26924050
3. Inactivation of the Pdgfd gene resulted in a mild phenotype in C57BL/6 mice, and the offspring was viable, fertile and generally in good health. PMID: 27032083
4. PDGF-D intensifies fibrogenesis by interfering with the fibrolytic activity of the TIMP-1/MMP-2/MMP-9 system, and PDGF-D signaling is mediated through both PDGF-alpha and -beta receptors. PMID: 25576870
5. Radial glia require PDGFD-PDGFRbeta signalling in human but not mouse neocortex PMID: 25391964
6. PDGF D represents a potentially promising target for prostate carcinoma treatment resistance in the absence of PTEN function, and warrants further laboratory evaluation and clinical study. PMID: 24331662
7. Data indicate that the proteolytic processing of full-length PDGF-D is required for PDGF-D activation of preosteoclasts, and that beta-PDGFR is present in activated osteoclasts. PMID: 22158043
8. identified PDGF-DD as an important target gene for antiangiogenic therapy due to its pleiotropic effects on vascular and non-vascular cells. PDGF-DD inhibition may offer new therapeutic options to treat neovascular diseases PMID: 20231273
9. Failure of laminin alpha4-mediated down-regulation of PDGF activity contributes to the progressive renal lesions in this animal model. PMID: 20035058
10. These results suggest that PDGF-D induce cellular transformation and promote tumour growth by accelerating the proliferation rate of the tumour cells, and by stimulation of tumour neovascularization. PMID: 12629513
11. splicing variant results in significant differences in peptide expression and function PMID: 12890490
12. PDGF-D plays an important role in the pathogenesis of tubulointerstitial injury through binding of PDGF-Rbeta in obstructive ureteral nephropathy PMID: 14514732
13. PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns. PMID: 19028801
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亞細胞定位：

Secreted.
蛋白家族：

PDGF/VEGF growth factor family
組織特異性：

Expressed at high levels in developing heart, lung, kidney and some muscle derivatives. Moderately expressed in liver, brain and testis. In the kidney, localized to glomerular mesangial cells and vascular smooth muscle cells. Up-regulated in areas of rena
數(shù)據(jù)庫鏈接：

KEGG: mmu:71785

STRING: 10090.ENSMUSP00000128388

UniGene: Mm.390122

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