Pcsk5 Antibody, Biotin conjugated

說明書

中文名稱：

Pcsk5兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA017644LD01MO
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Mus musculus (Mouse) Pcsk5 Polyclonal antibody
Uniprot No.：

Q04592
基因名：

Pcsk5
別名：

Pcsk5 antibody; Proprotein convertase subtilisin/kexin type 5 antibody; EC 3.4.21.- antibody; Proprotein convertase 5 antibody; PC5 antibody; Proprotein convertase 6 antibody; PC6 antibody; Subtilisin-like proprotein convertase 6 antibody; SPC6 antibody; Subtilisin/kexin-like protease PC5 antibody
宿主：

Rabbit
反應種屬：

Mouse
免疫原：

Recombinant Mouse Proprotein convertase subtilisin/kexin type 5 protein (117-452AA)
免疫原種屬：

Mus musculus (Mouse)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. May be responsible for the maturation of gastrointestinal peptides. May be involved in the cellular proliferation of adrenal cortex via the activation of growth factors.
基因功能參考文獻：
1. Pcsk5 may have an essential and early role in the cranio-cardiac mesoderm for heart development. PMID: 28446132
2. loss of the convertase furin or PC5/6 in hepatocytes results in a approximately 30% decrease in APC levels, with no significant contribution from PACE4. We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin activation. PMID: 28468828
3. Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy. PMID: 21681612
4. PCSK5 and GDF11 expression during hindgut morphogenesis could be key factors for normal anorectal development, which can be disturbed by the administration of an overdose of all-trans retinoic acid, leading to anorectal malformations. PMID: 21480163
5. Data suggest that intestinal PC5/6 is protective towards tumorigenesis, especially in mouse duodenum, and possibly in human colon. PMID: 19737405
6. large cysteine-rich region acts as an important part of functional domain of PC6 PMID: 15122044
7. PC6 is an essential molecule in modulating uterine function to support the establishment of embryo implantation PMID: 15601911
8. the CRD of PC5A and PACE4 functions as a cell surface anchor favoring the processing of their cognate surface-anchored substrates, including endothelial lipase PMID: 16135528
9. findings show that decidualized differentiation of stroma, which is a prerequisite for embryo implantation, leads to processing of lefty by PC5/6A PMID: 16141390
10. These results provide the first direct evidence that PC5 is involved in CCK processing PMID: 16266771
11. These data demonstrate that Pcsk5 is an essential gene. PMID: 16354705
12. the selectivity of PC5/6 for Gdf11 essentially resides in the presence of a P1' Asn in the RSRR downward arrowN cleavage motif PMID: 18378898
13. We propose that Pcsk5, at least in part via GDF11, coordinately regulates caudal Hox paralogs, to control anteroposterior patterning, nephrogenesis, skeletal, and anorectal development. PMID: 18519639
14. mouse G-cells express PC1/3, 2 and 5/6. we conclude that PC5/6 is without effect on progastrin. PMID: 18554181
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亞細胞定位：

[Isoform PC5A]: Secreted. Note=Secreted through the regulated secretory pathway.; [Isoform PC5B]: Endomembrane system; Single-pass type I membrane protein. Note=Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes.
蛋白家族：

Peptidase S8 family
組織特異性：

PC5A is expressed in most tissues but is most abundant in the intestine and adrenals. PC5B is expressed in the intestine, adrenals and lung but not in the brain.
數據庫鏈接：

KEGG: mmu:18552

STRING: 10090.ENSMUSP00000025618

UniGene: Mm.3401

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