Pcsk1 Antibody, FITC conjugated

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說明書

中文名稱：

Pcsk1兔多克隆抗體, FITC偶聯
貨號：

CSB-PA017640LC01RA
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Rattus norvegicus (Rat) Pcsk1 Polyclonal antibody
Uniprot No.：

P28840
基因名：

Pcsk1
別名：

Pcsk1 antibody; Bdp antibody; Nec-1 antibody; Nec1Neuroendocrine convertase 1 antibody; NEC 1 antibody; EC 3.4.21.93 antibody; Prohormone convertase 1 antibody; Proprotein convertase 1 antibody; PC1 antibody
宿主：

Rabbit
反應種屬：

Rat
免疫原：

Recombinant Rat Neuroendocrine convertase 1 protein (111-752AA)
免疫原種屬：

Rattus norvegicus (Rat)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
基因功能參考文獻：
1. macrophages from PC1/3 KO mice and rat PC1/3-KD NR8383 macrophages secreted more pro-inflammatory cytokines such as TNF-alpha, IL6, IL1alpha and CXCL2. PMID: 26778167
2. PC1/3 as an important regulator of vesicle trafficking and secretion in macrophages. PMID: 23637853
3. Chronic ethanol exposure decreases prohormone convertase (pc1/3) immunoreactivity in brain. PMID: 23050949
4. catalytic and P domains contribute to the folding and thermodynamic stability of the convertases through reciprocal hydrophobic interactions (prohormone convertase 3 [pc3/pc1]) PMID: 12721373
5. The prohormone convertase (PC) enzyme PC1 together with PC2 and PC5 may represent a redundant system to ensure production of biologically active cholecystokinin in rat brain. PMID: 14608596
6. proGHRH is initially cleave by furin at preproGHRH29-30, followed by a second cleavage at preproGHRH74 primarily by PC1 to generate GHRH and GHRH-RP peptides, respectively. PMID: 15146101
7. Leptin regulates hypothalamic PC1 expression and requires prohormone processing into mature peptides. PMID: 15286802
8. Prohormone-convertase 1 processing enhances post-Golgi sorting of prothyrotropin-releasing hormone-derived peptides PMID: 16204236
9. the prohormone convertase cleavage site within the alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway PMID: 16221685
10. The observed decrease in CCK seen with these RNAi treatments further supports a role for PC1 in CCK processing in these cells PMID: 16274843
11. Agouti-related protein is posttranslationally cleaved by proprotein convertase 1 to generate agouti-related protein (AGRP)83-132. PMID: 16384863
12. These data indicate that the transmembrane domain of PC3 plays a key role in sorting the enzyme to the regulated secretory pathway. PMID: 17240044
13. Ontogeny of ghrelin, obestatin, preproghrelin, and prohormone convertases in rat pancreas and stomach. PMID: 18784614
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亞細胞定位：

Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules.
蛋白家族：

Peptidase S8 family, Furin subfamily
數據庫鏈接：

KEGG: rno:25204

STRING: 10116.ENSRNOP00000015185

UniGene: Rn.11384

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