PYCR1 Antibody

中文名稱：

PYCR1兔多克隆抗體
貨號：

CSB-PA019115HA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA019115HA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA019115HA01HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PYCR1 Polyclonal antibody
Uniprot No.：

P32322
基因名：

PYCR1
別名：

PYCR1 antibody; Pyrroline-5-carboxylate reductase 1 antibody; mitochondrial antibody; P5C reductase 1 antibody; P5CR 1 antibody; EC 1.5.1.2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Pyrroline-5-carboxylate reductase 1, mitochondrial protein (2-319AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，PYCR1 Antibody (CSB-PA019115HA01HU)，的標記方式是Non-conjugated。對于PYCR1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA019115HB01HU	PYCR1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA019115HC01HU	PYCR1 Antibody, FITC conjugated
Biotin	CSB-PA019115HD01HU	PYCR1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress.
基因功能參考文獻：
1. we firmly establish biallelic mutations in POLR3A as the genetic cause of a recognizable, neonatal, Wiedemann-Rautenstrauch-like progeroid syndrome. Thus, we suggest that POLR3A mutations are causal for a portion of under-diagnosed early-onset segmental progeroid syndromes PMID: 30450527
2. Results indicate that single-nucleotide polymorphism (SNP)-derived mutations, R119G and G206W, enhance the rigidity of pyrroline-5-carboxylate reductase (P5CR) structure. PMID: 27677826
3. these findings revealed that the mRNA and protein PYCR1 levels were significantly related to the poor outcome in either ER-negative or ER-positive breast cancer. PYCR1 could serve as a prognostic biomarker, therapeutic target and predictive biomarker for breast cancers. PMID: 28379297
4. PYCR1 forms a concentration-dependent decamer in solution, consistent with the pentamer-of-dimers assembly seen crystallographically PMID: 28258219
5. Authors found that PYCR1 was highly expressed in prostate cancer tissues and then knocked down PYCR1 in PCa cell lines (DU145, PC-3 and LNCap) via lentivirus-mediated gene delivery and analyzed its biological function. PMID: 28078560
6. experimental results indicate the R119G mutation could be an involving pathomechanism for Autosomal recessive cutis laxa . PMID: 28194412
7. Silencing of both PYCR1 and PYCR2 completely abolished anti-oxidation activity of RRM2B, demonstrating a functional collaboration of these metabolic enzymes in response to oxidative stress. PMID: 26733354
8. confirming that indeed PYCR1 generates L-pipecolic acid from Delta(1)-piperideine-6-carboxylate PMID: 24431009
9. our current study presents the second largest group of patients with PYCR1-related ARCL and expands the clinical and genetic spectrum. PMID: 24035636
10. Identification of two new mutations in the PYCR1 gene in patients with autosomal recessive cutis laxa, type 2. PMID: 23531708
11. Data suggest that DJ-1 and PYCR1 are on the same pathway of anti-oxidative stress protection of the cells. PMID: 23743200
12. The findings presented here suggest a mutation screening of PYCR1 and cardiovascular survey in patients with De Barsy syndrome (DBS). PMID: 22052856
13. Mutation analysis revealed the presence of disease-causing variants in PYCR1, including a novel deletion of the entire PYCR1 gene in one family, and in each of the other patients the homozygous missense mutations. PMID: 21487760
14. A novel mutation in PYCR1 causes an autosomal recessive cutis laxa with premature aging features in a family. PMID: 21567914
15. The phenotype caused by PYCR1 mutations corresponds to geroderma osteodysplasticum rather than ARCL2B. PMID: 21204221
16. Mutagenesis and kinetic studies reveal the pivotal roles of the dinucleotide-binding Rossmann motif and residue Glu221 in the human enzyme Pyrroline-5-carboxylate reductase(P5CR). PMID: 16730026
17. In Autosomal-recessive cutis laxa type 2, a single nucleotide change leads to a missense mutation adjacent to a splice junction in the gene encoding PYCR1. PMID: 19576563
18. Mutations in PYCR1 cause cutis laxa with progeroid features. PMID: 19648921
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相關疾?。?/div>
Cutis laxa, autosomal recessive, 2B (ARCL2B); Cutis laxa, autosomal recessive, 3B (ARCL3B)
亞細胞定位：

Mitochondrion.
蛋白家族：

Pyrroline-5-carboxylate reductase family
數據庫鏈接：

HGNC: 9721

OMIM: 179035

KEGG: hsa:5831

STRING: 9606.ENSP00000328858

UniGene: Hs.163451

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