PTPN9 Antibody

中文名稱：

PTPN9兔多克隆抗體
貨號：

CSB-PA019045LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA019045LA01HU diluted at 1:400 and staining in paraffin-embedded human appendix tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA019045LA01HU diluted at 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PTPN9 Polyclonal antibody
Uniprot No.：

P43378
基因名：

PTPN9
別名：

MEG2 antibody; non-receptor type 9 antibody; protein tyrosine phosphatase antibody; Protein tyrosine phosphatase MEG2 antibody; Protein-tyrosine phosphatase MEG2 antibody; PTN9_HUMAN antibody; PTPase MEG2 antibody; Ptpn9 antibody; Tyrosine protein phosphatase non receptor type 9 antibody; Tyrosine-protein phosphatase non-receptor type 9 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Tyrosine-protein phosphatase non-receptor type 9 protein (221-339AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，PTPN9 Antibody (CSB-PA019045LA01HU)，的標記方式是Non-conjugated。對于PTPN9 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA019045LB01HU	PTPN9 Antibody, HRP conjugated	ELISA
FITC	CSB-PA019045LC01HU	PTPN9 Antibody, FITC conjugated
Biotin	CSB-PA019045LD01HU	PTPN9 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.
基因功能參考文獻：
1. Results from a study on gene expression variability markers in early-stage human embryos shows that PTPN9 is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
2. this study highlights an important role for miR-96 in the regulation of PTPN9 in breast cancer cells and may provide insight into the molecular mechanisms of breast carcinogenesis. PMID: 27857177
3. Expression of MEG2 is reversely correlated with that of miR-181a-5p in gastric cancer. PMID: 28747184
4. PTPN9 inhibited cell proliferation in HepG2 cells. PMID: 26715439
5. PTPMeg2 is an important phosphatase for the dephosphorylation of STAT3 and plays a critical role in breast cancer development. PMID: 22394684
6. This study indentified VEGFR2 as a PTPN9 substrate, and indicated that PTPN9 is a negative regulator of VEGFR2 signaling and function in endothelial cells. PMID: 22763125
7. data suggest PTPN9 as a negative regulator of breast cancer cells by targeting ErbB2 and EGFR and inhibiting STAT activation PMID: 20335174
8. Purification and characterization of protein tyrosine phosphatase PTP-MEG2 PMID: 12112018
9. PTP-MEG2 has an important role in the development of erythroid cells. PMID: 12920026
10. PTPase-MEG2 through its Sec14p homology domain couples inositide phosphorylation to tyrosine dephosphorylation and the regulation of intracellular traffic of the secretory pathway in T cells. PMID: 14662869
11. PTP-MEG2 reduced the phosphotyrosine content of NSF and co-localized with NSF and syntaxin 6 in intact cells, the first demonstrated role for a protein tyrosine phosphatase in the regulated secretory pathway PMID: 15322554
12. role in the negative regulation of hepatic insulin signaling PMID: 16679294
13. the N terminus of PTPMEG2 is necessary for the targeting of this phosphatase to the secretory vesicle compartment by association with other proteins involved in intracellular transport. PMID: 17387180
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亞細胞定位：

Cytoplasm.
蛋白家族：

Protein-tyrosine phosphatase family, Non-receptor class 3 subfamily
數據庫鏈接：

HGNC: 9661

OMIM: 600768

KEGG: hsa:5780

STRING: 9606.ENSP00000303554

UniGene: Hs.445775

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