PTPN18 Antibody

說明書

產品詳情

Uniprot No.：

Q99952
基因名：

PTPN18
別名：

BDP 1 antibody; Brain derived phosphatase antibody; Brain-derived phosphatase antibody; Protein tyrosine phosphatase non receptor type 18 antibody; Protein tyrosine phosphatase non receptor type 18 brain derived antibody; PTN18_HUMAN antibody; PTP HSCF antibody; PTPN 18 antibody; PTPN18 antibody; Tyrosine protein phosphatase non receptor type 18 antibody; Tyrosine-protein phosphatase non-receptor type 18 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human PTPN18
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.
基因功能參考文獻：
1. PTPN12, PTPRN and PTPN18 were independent prognostic factors in Hepatocellular Carcinoma. PMID: 29742497
2. PTPN18 regulates HER2-mediated cellular functions through defining both its phosphorylation and ubiquitination barcodes. PMID: 25081058
3. BDP1 has a role in negative regulation of HER2 signaling PMID: 14660651
4. novel isoform of PTPN18 based on analysis of expressed sequence tags was discovered; deletion of 4 exons in the catalytic domain of the isoform may alter enzymatic activity; 2 of the novel isoform predictions were experimentally validated through RT-PCR PMID: 16303740
亞細胞定位：

Nucleus. Cytoplasm.
蛋白家族：

Protein-tyrosine phosphatase family, Non-receptor class 4 subfamily
組織特異性：

Expressed in brain, colon and several tumor-derived cell lines.
數據庫鏈接：

HGNC: 9649

OMIM: 606587

KEGG: hsa:26469

STRING: 9606.ENSP00000175756

UniGene: Hs.516390

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