PTPN14 Antibody, FITC conjugated

說明書

中文名稱：

PTPN14兔多克隆抗體, FITC偶聯
貨號：

CSB-PA623010LC01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PTPN14 Polyclonal antibody
Uniprot No.：

Q15678
基因名：

PTPN14
別名：

Cytoskeletal associated protein tyrosine phosphatase antibody; MGC126803 antibody; PEZ antibody; Phosphatase with ezrin domain antibody; Protein tyrosine phosphatase non receptor type 14 antibody; Protein tyrosine phosphatase pez antibody; Protein-tyrosine phosphatase pez antibody; PTN14_HUMAN antibody; PTP 36 antibody; PTP36 antibody; PTPD 2 antibody; PTPN 14 antibody; PTPN14 antibody; Tyrosine protein phosphatase non receptor type 14 antibody; Tyrosine-protein phosphatase non-receptor type 14 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Tyrosine-protein phosphatase non-receptor type 14 protein (220-351AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor.
基因功能參考文獻：
1. p53 deficiency promotes Yap signaling and that PTPN14 and TP53 mutations are mutually exclusive in human cancers. PMID: 29017057
2. study determined that high-risk E7 proteins target the proteolysis of the cellular protein tyrosine phosphatase PTPN14 and find that this activity is correlated with the retinoblastoma-independent transforming activity of E7 PMID: 27651363
3. PTPN14 is classified as a potential tumor suppressor protein, and is very susceptible to HPV E7-induced proteasome-mediated degradation. PMID: 28100625
4. The Hippo signaling pathway was significantly associated with ER-negative breast cancer (pathway level P = 0.02). Gene-based analyses revealed that CDH1 was responsible for the pathway association (P < 0.01),corrected P = 0.02). rs142697907 in PTPN14 was associated with ER-positive breast cancer and rs2456773 in CDK1 with ER-negativity in case-only analysis after gene-level correction PMID: 27485598
5. PTPN14, a Pez mammalian homolog, is degraded by overexpressed Su(dx) or Su(dx) homologue WWP1 in mammalian cells. PMID: 25814387
6. Findings indicate a pathway involving protein-tyrosine phosphatase D2 PTPD2 (PTPN14) and the lipid second messenger phosphatidic acid that promotes ERBB2 receptor function. PMID: 25681440
7. results indicate a potential regulatory role of PTPN14 in the Hippo pathway and demonstrate another layer of regulation in the YAP oncogenic function PMID: 25023289
8. Data demonstrate that PTPN14 downregulation can phenocopy YAP activation in mammary epithelial cells and synergize with YAP to induce oncogenic transformation. PMID: 23613971
9. Data show that p130 Crk-associated substrate is a direct substrate of PTPN14 and that PTPN14 specifically regulates p130Cas phosphorylation at tyrosine residue 128 in colorectal cancer cells. PMID: 22710723
10. YAP is a direct substrate of PTPN14. Results indicate a potential regulatory role of PTPN14 on YAP and demonstrate a novel mechanism in YAP regulation. PMID: 22525271
11. YAP forms a protein complex with PTPN14 through the WW domains of YAP and the PPXY motifs of PTPN14. PMID: 22689061
12. that PTPN14 acts to suppress cell proliferation by promoting cell density-dependent cytoplasmic translocation of YAP1 PMID: 22948661
13. PTPN14 has a role in angiogenesis and/or arteriovenous fate, acting via EphrinB2 and ACVRL1/activin receptor-like kinase 1 PMID: 22233626
14. These results suggest a unique and conserved role for PTPN14 in the regulation of lymphatic development in mammals and a nonconserved role in choanal development in humans. PMID: 20826270
15. results provide a high-resolution crystal structure of the phosphatase PTPN14, thereby providing insight into its distinct substrate specificity and identifying unique structural features PMID: 16534812
16. Dysregulation of TGFbeta signaling as a possible link between Pez mutation and cancer progression. PMID: 18677119
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相關疾病：

Choanal atresia and lymphedema (CHATLY)
亞細胞定位：

Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Translocation into the nucleus is associated with induction of cell proliferation. Partially colocalized with actin filaments at the plasma membrane.
蛋白家族：

Protein-tyrosine phosphatase family, Non-receptor class subfamily
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 9647

OMIM: 603155

KEGG: hsa:5784

STRING: 9606.ENSP00000355923

UniGene: Hs.193557

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