PTPN12 Antibody, HRP conjugated
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中文名稱：PTPN12兔多克隆抗體, HRP偶聯(lián)
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貨號(hào)：CSB-PA019026LB01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) PTPN12 Polyclonal antibody
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Uniprot No.：
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基因名：PTPN12
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別名：Protein tyrosine phosphatase G1 antibody; Protein tyrosine phosphatase non receptor type 12 antibody; Protein-tyrosine phosphatase G1 antibody; PTN12_HUMAN antibody; PTP PEST antibody; PTP-PEST antibody; PTPG1 antibody; Ptpn12 antibody; Tyrosine protein phosphatase non receptor type 12 antibody; Tyrosine-protein phosphatase non-receptor type 12 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Tyrosine-protein phosphatase non-receptor type 12 protein (539-714AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
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靶點(diǎn)詳情
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功能：Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248'.
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基因功能參考文獻(xiàn)：
- identified a new phosphorylation-based substrate recognition mechanism of PTPN12 by CDK2, which orchestrated signaling crosstalk between the oncogenic CDK2 and HER2 pathways PMID: 28842430
- PTPN12 plasmid transfection increased PTPN12 mRNA and protein expressions, suppressed cell proliferation and migration, reduced EGFR level, and enhanced caspase 3 activity compared with control and empty plasmid groups. PMID: 29634414
- PTPN12, PTPRN and PTPN18 were independent prognostic factors in Hepatocellular Carcinoma. PMID: 29742497
- Here, solved is a crystal structure of the native PTPN12 catalytic domain with the catalytic cysteine (residue 231) in dual conformation (phosphorylated and unphosphorylated). PMID: 29278368
- this study, with a relative large population, showed that PTPN12 eQTL SNP may interact with HBV mutation on HCC risk. PMID: 27075395
- MyoVa-Ca(2+) channel interactions are required for proper long-range axon growth in developing spinal cord in vivo. PMID: 27134172
- PTP-PEST regulates EphA3 activation both by affecting cytoskeletal remodelling and through its direct action as a PTP controlling EphA3 phosphorylation. PMID: 26644181
- Study suggests that PTPN12 expression is a valuable prognostic biomarker for non-small cell lung cancer. PMID: 25868976
- PTPN12 expression decreases in human renal cell carcinoma PMID: 26537073
- The decrease expression of PTPN12 might be important in conferring a more aggressive behavior in NPC. Thus, PTPN12 expression may be used as a novel independent prognostic biomarker for patients with NPC. PMID: 25663493
- PTPN12 is potentially a methylation-silenced TSG for breast cancer that may play an important role in breast carcinogenesis and could potentially serve as an independent prognostic factor for invasive breast cancer patients. PMID: 23044628
- Decreased expression of PTPN12 correlates with tumor recurrence and poor survival of patients with hepatocellular carcinoma. PMID: 24475046
- these data suggest that PTP-PEST affects epithelial cell motility by controlling the distribution and phosphorylation of p120 and its availability to control Rho GTPase activity. PMID: 24284071
- The involvement of PTPN12 in the antioxidant response of breast cancer cells suggests that PTPN12 may represent a novel therapeutic target for this disease PMID: 23435421
- Overexpression of PTPN12 inhibited proliferation and migration in OSCC cells. PMID: 23733313
- MRNAs of PTPN12, MSH6, and ZEB1 orthologous genes from different animal species have binding sites for hsa-miR-1279 which consist of homologous oligonucleotides encoding similar human oligopeptides PMID: 23957009
- High expression of PTPN12 is associated with favorable disease free survival in esophageal squamous cell carcinoma patients. PMID: 22429674
- activated Ras induces extracellular signal-regulated kinase 1 and 2-dependent phosphorylation of PTP-PEST at S571, which recruits PIN1 to bind to PTP-PEST PMID: 21876001
- Using a genetic screen, study identifies the PTPN12 tyrosine phosphatase as a tumor suppressor in PMID: 21376233
- PTP-PEST functions as a suppressor of epithelial cell motility by controlling Rho GTPase activity and the assembly of adherens junctions. PMID: 20519451
- PTP-PEST actively contributes to the cellular apoptotic response and reveal the importance of caspases as regulators of PTPs in apoptosis. PMID: 17130234
- These data demonstrate that LPXN forms a signaling complex with Pyk2, c-Src, and PTP-PEST to regulate migration of prostate cancer cells. PMID: 17329398
- No association was detected between individual PTPN12 tag SNPs and GD but preliminary evidence suggests PTPN12 confers an increased risk of mild/moderate ophthalmopathy (NOSPECS classes 2-4) and that PTPN12 interacts with the TSHR. PMID: 17608818
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亞細(xì)胞定位：Cytoplasm. Cell junction, focal adhesion. Cell projection, podosome.
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蛋白家族：Protein-tyrosine phosphatase family, Non-receptor class 4 subfamily
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