PRSS2 Antibody

中文名稱：

PRSS2兔多克隆抗體
貨號：

CSB-PA018814LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Mouse heart tissue, Mouse liver tissue, Mouse brain tissue, Mouse kidney tissue
All lanes: PRSS2 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 27 kDa
Observed band size: 27 kDa

Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA018814LA01HU at dilution of 1:100
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靶點詳情

產品詳情

產品描述：

CUSABIO's product CSB-PA018814LA01HU is a PRSS2 polyclonal antibody raised in the rabbit against the recombinant human PRSS2 protein (24-247AA). It exists as the unconjugated IgG isoform. It is purified by protein G and reaches up to 95% in purity. And it shows reactivity with human and mouse samples. This PRSS2 antibody can recognize PRSS2 protein in ELISA, WB, and IHC applications. The PRSS2 protein is found at high levels in pancreatic juice and is upregulated in human pancreatitis and chronic alcoholism.
產品名稱：

Rabbit anti-Homo sapiens (Human) PRSS2 Polyclonal antibody
Uniprot No.：

P07478
基因名：

PRSS2
別名：

Anionic trypsinogen antibody; EC 3.4.21.4 antibody; MGC111183 antibody; MGC120174 antibody; Protease serine 2 preproprotein antibody; Protease; serine; 2 (trypsin 2) antibody; Protease; serine; 2 antibody; Protease; serine; 2; preproprotein antibody; Prss2 antibody; Serine protease 2 antibody; TRY2 antibody; TRY2_HUMAN antibody; TRY8 antibody; TRYP2 antibody; Trypsin 2 antibody; Trypsin II antibody; Trypsin-2 antibody; Trypsinogen 2 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Trypsin-2 protein (24-247AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，PRSS2 Antibody (CSB-PA018814LA01HU)，的標記方式是Non-conjugated。對于PRSS2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA018814LB01HU	PRSS2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA018814LC01HU	PRSS2 Antibody, FITC conjugated
Biotin	CSB-PA018814LD01HU	PRSS2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

In the ileum, may be involved in defensin processing, including DEFA5.
基因功能參考文獻：
1. evaluated the association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic recurrent acute (RAP) and chronic pancreatitis PMID: 26110235
2. PRSS2 single nucleotide polymorphism associated with the development of alcoholic pancreatitis. PMID: 25253127
3. Serum trypsinogen-2 is associated with pancreatic cancer and pancreatitis. PMID: 25916077
4. trypsin-2 over-expression enhanced tongue carcinoma cell invasion by various genetic and proteolytic mechanisms. PMID: 22909050
5. Elevation of urine trypsinogen 2 is an independent risk factor for pancreatic fistula after pancreaticoduodenectomy. PMID: 22357509
6. Report a simple, rapid, easy, and noninvasive urinary trypsinogen-2 test can diagnose or rule out most cases of acute pancreatitis. PMID: 22481290
7. Data show that urinary trypsinogen-2 dipstick test is a useful test for early diagnosis of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. PMID: 21946810
8. results suggest that trypsinogen-2 is a more sensitive marker than amylase, and it can be useful in early diagnosis of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. PMID: 21792081
9. A genetic variant of PRSS2 may contribute to the low prevalence of pancreatitis in primary hyperparathyroidism patients. PMID: 20625975
10. Hyperexpression of the PRSS2 gene is associated with pancreatic cancer. PMID: 20428826
11. there was a borderline statistically significant association between pancreatic cancer and HAT/HCT but no association between pancreatic cancer and HAT, HCT. PMID: 20484960
12. Urine trypsinogen-2 test may be an important diagnostic tool in excluding the diagnosis of acute pancreatitis; it has a negative predictive value. PMID: 20517765
13. Results do not support the urinary trypsinogen-2 dipstick test (UTDT) to replace standard plasma amylase for the diagnosis of AP, however, the test demonstrated an adequate sensitivity to be used for rapid early screening of AP in daily clinics. PMID: 19752771
14. Results indicate that up-regulation of anionic trypsinogen in pancreatic diseases does not affect physiological trypsinogen activation, but significantly limits trypsin generation under potential pathological conditions. PMID: 12709065
15. High levels of pulmonary trypsin-2 may be associated with the development of bronchopulmonary dysplasia in preterm infants. PMID: 12949286
16. G191R variant of PRSS2 mitigates intrapancreatic trypsin activity and thereby protects against chronic pancreatitis PMID: 16699518
17. Our results suggest that serum trypsinogen-2 is a most useful marker for diagnosing patients with cholangiocarcinoma, and it is superior to serum CA19-9 and CEA. PMID: 17640760
18. Co-localization of trypsin-2 and MMP-9 resulted in intracellular proMMP-9 processing that represented fully or partially activated MMP-9. PMID: 18062964
19. A loss of function polymorphism (G191R) of anionic trypsinogen (PRSS2) confers protection against chronic pancreatitis. PMID: 18362849
20. A fusion with PRSS1 is associated with hereditary pancreatitis. PMID: 18461367
21. primary role of trypsinogen sulfation in humans is to stimulate autoactivation of PRSS1 PMID: 18986305
22. The p.G191R variant protected against alcoholic and idiopathic chronic pancreatitis as well as alcoholic acute pancreatitis in Japan. PMID: 19052022
23. G191R PRSS2 is a rare allele in the Indian population and the data suggest a nonsignificant trend towards a protective effect from tropical calcific pancreatitis in Indians. PMID: 19077465
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亞細胞定位：

Secreted, extracellular space.
蛋白家族：

Peptidase S1 family
組織特異性：

Expressed in Paneth cells, at the base of small intestinal crypts.
數據庫鏈接：

HGNC: 9483

OMIM: 601564

KEGG: hsa:5645

UniGene: Hs.449281

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