PRND Antibody
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中文名稱：PRND兔多克隆抗體
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貨號：CSB-PA890741ESR2HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA890741ESR2HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PRND Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：dJ1068H6.4 antibody; DPL antibody; Dublet antibody; MGC41841 antibody; Prion gene complex downstream antibody; Prion like protein doppel antibody; Prion protein 2 (dublet) antibody; Prion protein 2 antibody; Prion-like protein doppel antibody; PRND antibody; PRND_HUMAN antibody; PrPLP antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Prion-like protein doppel protein (20-160AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Required for normal acrosome reaction and for normal male fertility. Can bind Cu(2+).
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基因功能參考文獻：
- results demonstrate that blocking doppel can control VEGF signaling in TECs and selectively inhibit tumor angiogenesis. PMID: 26950422
- The association between the APOE, CYP46, PRNP and PRND genes and the profile of neuropsychiatric symptoms in Polish subjects with Alzheimer's disease and mild cognitive impairment, was evaluated. PMID: 22453181
- in astrocytomas, Dpl undergoes different molecular processes that might constitute additional helpful tools to characterize the glial tumor progression PMID: 20981146
- Cytotoxicity induced by the expression of Dpl and truncated PrP in neural derived cells are closely related with the apoptosis process. PMID: 19728151
- expression pattern and biochemical characteristics in human tissues and in Chinese hamster ovary cells transfected with wild-type or variant human Dpl gene constructs PMID: 12200435
- Doppel expression is not modified in the brains of patients with Creutzfeldt-Jakob disease. PMID: 12586339
- human Doppel fails to interact with itself; Dpl and PrP are not related or are only marginally related with respect to their ligand binding behaviour PMID: 15158907
- results demonstrate that Doppel and PrPc co-patch extensively at the plasma membrane PMID: 15203115
- Doppel interacts with the full-length laminin receptor precursor protein PMID: 15246873
- Doppel is expressed early during ontogenesis, and is found in both germ cells and Sertoli cells. Doppel may play a physiological role in acrosome biogenesis. PMID: 16421231
- Extensive differences in PRND gene expression were also found within each grade of malignancy, suggesting that PRND mRNA quantitation might be useful to distinguish astrocytoma subtypes. PMID: 17390034
- Study provides the foundation for further study of Dpl biological functions in vitro and in vivo. PMID: 17894227
- Results might suggest a potential and functional role for Dpl in tumor cells migratory and morphological behaviours and address to future gene-targeted therapeutic interventions. PMID: 18936526
- results suggested that the function of Dpl is antagonistic to PrP rather than synergistic PMID: 19129949
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亞細胞定位：Cell membrane; Lipid-anchor, GPI-anchor.
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蛋白家族：Prion family
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組織特異性：Expressed in testis, in Sertoli cells, ejaculated spermatozoa and in seminal fluid (at protein level).
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數據庫鏈接：
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