PRMT3 Antibody

說明書

中文名稱：

PRMT3兔多克隆抗體
貨號：

CSB-PA948631
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA948631(PRMT3 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA948631(PRMT3 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

O60678
基因名：

PRMT3
別名：

2010005E20Rik antibody; 2410018A17Rik antibody; AL033309 antibody; ANM3_HUMAN antibody; Heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 3 antibody; Heterogeneous nuclear ribonucleoprotein methyltransferase like 3 antibody; Heterogeneous nuclear ribonucleoprotein methyltransferase like protein 3 antibody; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 antibody; HMT1 hnRNP methyltransferase like 3 antibody; HMT1 hnRNP methyltransferase like 3 S. cerevisiae antibody; HMT1-like 3 antibody; hnRNP methyltransferase like 3 antibody; HRMT1L3 antibody; PRMT 3 antibody; PRMT3 antibody; Protein arginine methyltransferase 3 antibody; Protein arginine N methyltransferase 3 antibody; Protein arginine N-methyltransferase 3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthetic peptide of Human PRMT3
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:10000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Protein-arginine N-methyltransferase that catalyzes both the monomethylation and asymmetric dimethylation of the guanidino nitrogens of arginine residues in target proteins, and therefore falls into the group of type I methyltransferases. May regulate retinoic acid synthesis and signaling by inhibiting ALDH1A1 retinal dehydrogenase activity.
基因功能參考文獻：
1. Findings uncover the existence of an extra-ribosomal complex consisting of PDCD2L, RPS2, and PRMT3 and support a role for PDCD2L in the late maturation of 40S ribosomal subunits. PMID: 27697862
2. This work profilies substrates of protein arginine N-methyltransferase 3 with S-adenosyl-L-methionine analogues. PMID: 24320160
3. Mutational defects in PRMT3 is not the cause of frontotemporal lobar degeneration. PMID: 23635657
4. results show that protein arginine methyl transferase (PRMT)-3 and -5 methylate NaV1.5 in vitro, interact with NaV1.5 in human embryonic kidney (HEK) cells, and increase NaV1.5 current density PMID: 23912080
5. The crystal structure of PRMT3 in complex with an inhibitor as well as kinetic analysis reveals an allosteric site of inhibition. PMID: 22795084
6. release of VHL30 from the E3 ligase complex, promotes the binding of VHL30 to a protein arginine methyltransferase, PRMT3 PMID: 21942715
7. The Tyr87Cys and Tyr87Glu-PRMT3 variants had markedly decreased affinity to ribosomal protein S2 and, consequently, reduced enzymatic activity compared to the wild-type enzyme. PMID: 21059412
8. PRMT3 is a ribosomal protein methyltransferase that affects the cellular level of ribosomal subunits. PMID: 15175657
9. DAL-1/4.1B protein significantly inhibits PRMT3 methylation of cellular substrates, which may affect mechanism through which DAL-1/4.1B affects tumor cell growth. PMID: 15334060
10. Type I Arginine Methyltransferases PRMT1 and PRMT-3 Act Distributively PMID: 19158082
11. results suggest that the pathological mutation in the PABPN1 gene alters the protein conformation and induces a preferential interaction with type I PRMTs and Hsp70 chaperones PMID: 19641605
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亞細胞定位：

Cytoplasm.
蛋白家族：

Class I-like SAM-binding methyltransferase superfamily, Protein arginine N-methyltransferase family
數據庫鏈接：

HGNC: 30163

OMIM: 603190

KEGG: hsa:10196

STRING: 9606.ENSP00000331879

UniGene: Hs.152337

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