PRKCSH Antibody
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中文名稱(chēng)：PRKCSH兔多克隆抗體
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貨號(hào)：CSB-PA02925A0Rb
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規(guī)格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA02925A0Rb at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA02925A0Rb at dilution of 1:100
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱(chēng)：Rabbit anti-Homo sapiens (Human) PRKCSH Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：80K-H protein antibody; AGE-binding receptor 2 antibody; AGE-R2 antibody; G19P1 antibody; GLU2B_HUMAN antibody; Glucosidase 2 subunit beta antibody; Glucosidase II beta subunit antibody; Glucosidase II subunit beta antibody; Hepatocystin antibody; PCLD antibody; PKCSH antibody; PLD1 antibody; PRKCSH antibody; Protein kinase C substrate 60.1 kDa protein heavy chain antibody; Protein kinase C substrate 80 Kda protein antibody; Protein kinase C substrate 80K-H antibody; Protein kinase C substrate; 80 Kda protein antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Glucosidase 2 subunit beta protein (15-302AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
本頁(yè)面中的產(chǎn)品，PRKCSH Antibody (CSB-PA02925A0Rb)，的標(biāo)記方式是Non-conjugated。對(duì)于PRKCSH Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：
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克隆類(lèi)型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia.
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基因功能參考文獻(xiàn)：
- Results suggest that loss of PRKCSH and SEC63 leads to general defects in ciliogenesis, while quenching of the Wnt signaling cascade is cholangiocyte-restricted. PMID: 28973524
- This study demonstrated that Large copy number variations on germline level are not present in patients with a clinical diagnosis of Severe Polycystic Liver Disease. PMID: 26365003
- Polycystic liver disease is recessive at the cellular level, and loss of functional PRKCSH is an important step in cystogenesis. PMID: 21856269
- The induction of autophagy by hepatocystin deficiency is mediated through mammalian target of rapamycin (mTOR). PMID: 21681021
- Results provide evidence that mutations at the coding PRKCSH GAG repeat are a target of MSI and are selectively associated with the MSI-H phenotype in gastric carcinomas. PMID: 21371016
- The common SNPs tested in DDOST, PRKCSH and LGALS3 do not seem to be associated with diabetic micro- or macrovascular complications or with type 1 diabetes in Finnish patients. PMID: 20490454
- identified a total of 26 novel mutations in PRKCSH (n = 14) and SEC63 (n = 12), including four splice site mutations, eight insertions/ deletions, six non-sense mutations, and eight missense mutations PMID: 20095989
- Our results suggest that PRKCSH gene is not a major genetic cause of PCLD and there may be at least another locus responsible for the disease in Taiwan. PMID: 19308730
- PRKCSH functions as a chaperone-like molecule, which prevents endoplasmic reticulum-associated degradation of TRPP2. PMID: 19801576
- Mutations in this protein cause isolated autosomal dominant polycystic liver disease. PMID: 12529853
- germline mutations in PRKCSH as the probable cause of autosomal dominant polycystic liver disease PMID: 12577059
- autosomal dominant polycystic liver disease is genetically heterogeneous PMID: 15057895
- role of hepatocystin in carbohydrate processing and quality control of newly synthesized glycoproteins in the endoplasmic reticulum PMID: 15188177
- results identify 80K-H as a new player involved in GLUT4 vesicle transport and identify a link between a kinase involved in the insulin signalling cascade, PKCzeta, and a known component of the GLUT4 vesicle trafficking pathway, munc18c PMID: 15707389
- the majority of cysts from PRKCSH mutation carriers did not express hepatocystin PMID: 18224332
- Hepatocystin is not secreted in liver cyst fluids of autosomal dominant polycystic liver disease patients, suggesting that mutant hepatocystin is either not produced or degraded intracellularly. PMID: 18419150
- 80K-H is a novel regulator of IP3R1 activity, and it may contribute to neuronal functions. PMID: 18990696
- These results indicate that insulin induces dynamic associations between PKCzeta, 80K-H, and munc18c and that 80K-H may act as a key signaling link between PKCzeta and munc18c in live cells. PMID: 19061073
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相關(guān)疾病：Polycystic liver disease 1 (PCLD1)
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亞細(xì)胞定位：Endoplasmic reticulum.
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數(shù)據(jù)庫(kù)鏈接：
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