PRKAR2B Antibody

說明書

中文名稱：

PRKAR2B兔多克隆抗體
貨號：

CSB-PA003794
規(guī)格：

￥1090
圖片：
Western Blot analysis of 3T3 cells using PKA IIβ reg Polyclonal Antibody

Western Blot analysis of NIH-3T3 K562 HepG2 cells using PKA IIβ reg Polyclonal Antibody
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

P31323
基因名：

PRKAR2B
別名：

AI451071 antibody; AW061005 antibody; cAMP dependent protein kinase type II beta regulatory chain antibody; cAMP dependent protein kinase type II beta regulatory subunit antibody; cAMP-dependent protein kinase type II-beta regulatory subunit antibody; H RG363E19.2 antibody; KAP3_HUMAN antibody; MGC116401 antibody; Pkarb2 antibody; PRKAR 2 antibody; PRKAR2 antibody; PRKAR2B antibody; Protein kinase cAMP dependent regulatory type II beta antibody; RATDNA antibody; RII beta antibody; RII(beta) antibody; RIIbeta antibody; WUGSC:H RG363E19.2 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from Human PKA IIβ reg around the non-phosphorylation site of S113.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應用范圍：

WB, IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:10000

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
基因功能參考文獻：
1. Study identified the overexpression of PRKAR2B in castration-resistant prostate cancer (CRPC) mouse models and patients, and showed it promoted CRPC cell proliferation, invasion and survival by mainly modulates cell cycle gene expression. These results provide evidence that PRKAR2B is a novel oncogenic gene in CRPC. PMID: 28008150
2. Release of pRIIbeta in the presence of cAMP is reduced by calcium, whereas autophosphorylation at the phosphorylation site inhibits holoenzyme reassociation with the catalytic subunit. PMID: 26158466
3. Because of limited power, PRKAR2B's role in antipsychotic-induced weight gain is unclear, but biological evidence suggests that PRKAR2B may be involved PMID: 24737441
4. Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 21068099
5. Clinical trial and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20195266
6. lipolytic catecholamine resistance of sc adipocytes in polycystic ovary syndrome is probably due to a combination of decreased amounts of beta(2)-adrenergic receptors, the regulatory II beta-component of protein kinase A, and hormone-sensitive lipase PMID: 12727985
7. Nuclear RII beta can act as a repressor of CREB transcriptional activity in T cells, providing a potential functional significance for aberrant levels of nuclear RII beta in systemic lupus erythematosus T cells. PMID: 14500661
8. there are abnormalities in [3H]cAMP binding and catalytic activity kinase A in brain of depressed suicide victims, which could be due to reduced expression of RIIbeta and Cbeta PMID: 14744463
9. serine 114 phosphorylation and nuclear localization of RIIbeta controls the regulation of IL-2 gene expression in T cells. PMID: 15187164
10. Loss of PRKAR2B protein due to a post-transcriptional mechanism in ACA-S is a new mechanism of cAMP pathway dysregulation in adrenocortical tumorigenesis. PMID: 18505904
11. PKA RII(beta) is responsible for increased glucocorticoid sensitivity, critical for cAMP-mediated synergistic cell killing in CEM cells PMID: 18544528
12. both the constitutive and cAMP-induced release of TNFR1 exosome-like vesicles occur via PKA-dependent pathways that are regulated by the anchoring of RIIbeta to BIG2 via AKAP domains B and C PMID: 18625701
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亞細胞定位：

Cytoplasm. Cell membrane. Note=Colocalizes with PJA2 in the cytoplasm and at the cell membrane.
蛋白家族：

CAMP-dependent kinase regulatory chain family
組織特異性：

Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
數(shù)據(jù)庫鏈接：

HGNC: 9392

OMIM: 176912

KEGG: hsa:5577

STRING: 9606.ENSP00000265717

UniGene: Hs.433068

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