PRKAG1 Antibody

中文名稱：

PRKAG1兔多克隆抗體
貨號(hào)：

CSB-PA01149A0Rb
規(guī)格：

￥440
圖片：
Western Blot
Positive WB detected in: Rat liver tissue
All lanes: PRKAG1 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 38, 35, 39 kDa
Observed band size: 38 kDa

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA01149A0Rb at dilution of 1:100

Immunofluorescent analysis of PC-3 cells using CSB-PA01149A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
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靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) PRKAG1 Polyclonal antibody
Uniprot No.：

P54619
基因名：

PRKAG1
別名：

5' AMP activated protein kinase gamma 1 subunit antibody; 5' AMP activated protein kinase subunit gamma 1 antibody; 5''-AMP-activated protein kinase subunit gamma-1 antibody; AAKG1_HUMAN antibody; AMP activated protein kinase noncatalytic gamma 1 subunit antibody; AMPK gamma 1 chain antibody; AMPK gamma1 antibody; AMPK subunit gamma-1 antibody; AMPKg antibody; MGC8666 antibody; PRKAG 1 antibody; PRKAG1 antibody; Protein kinase AMP activated gamma 1 non catalytic subunit antibody; protein kinase; AMP-activated; noncatalytic gamma-1 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human, Rat
免疫原：

Recombinant Human 5\'-AMP-activated protein kinase subunit gamma-1 protein (1-331AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，PRKAG1 Antibody (CSB-PA01149A0Rb)，的標(biāo)記方式是Non-conjugated。對(duì)于PRKAG1 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA01149B0Rb	PRKAG1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA01149C0Rb	PRKAG1 Antibody, FITC conjugated
Biotin	CSB-PA01149D0Rb	PRKAG1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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靶點(diǎn)詳情

功能：

AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
基因功能參考文獻(xiàn)：
1. Data suggest different gamma-isoforms in AMPK can have different effects on enzyme activation; here, activation of AMPK by compound 991 is greater if AMPK contains PRKAG2 versus PRKAG1 or PRKAG3. PMID: 28302767
2. Pin1 plays an important role in the pathogenic mechanisms underlying impaired glucose and lipid metabolism, functioning as a negative regulator of AMPK PMID: 26276391
3. Letter: report PRKAG1 frameshift mutations in colorectal cancer. PMID: 25267969
4. Electrogenic phosphate transport in sodium/phosphate cotransporter NaPi-IIa-expressing Xenopus oocytes is markedly decreased by the coexpression of constitutively active AMPKgammaR70Q, but not of AMPK(alphaK45R). PMID: 24356547
5. PRKAG1 interacts with DSCAM through its gamma subunit, and netrin-1 activates AMPK phosphorylation in cortical neurons. PMID: 23479427
6. Conclude that cTnI phosphorylation by AMPK may represent a novel mechanism of regulation of cardiac function. PMID: 22456184
7. Inhibition of the KCa3.1 channels by AMP-activated protein kinase in human airway epithelial cells. PMID: 19052260
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蛋白家族：

5'-AMP-activated protein kinase gamma subunit family
數(shù)據(jù)庫鏈接：

HGNC: 9385

OMIM: 602742

KEGG: hsa:5571

STRING: 9606.ENSP00000323867

UniGene: Hs.530862

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